Shenzhen Intellirocks Tech. Co., Ltd.

Shenzhen Qianyan Technology Ltd

Biotheus Inc.

Other

Zhongkai University of Agriculture and Engineer

Weifeng Huang

Wenlong Wu

Zhijun Yuan

Andy Tsun

Cheng Gong

Li Liu

Yu Lin Tang

Shaoming Luo

Chaojun Hou

Jiajun Zhuang

Cheng Chen

Zhenyu Zhong

Jintian Lin

Dongjun Ding

Lixue Zhu

Tianhang Zhai

Xiaoniu Miao

Joanne Tsoyue Sun

Yifeng Xu

Tsoyue Joanne Sun

Huan Lei

Lirui Tian

Zaili Chen

Pian Wang

Provided is a complementary determining region (CDR) of a VHH chain of an anti-PD-L1 single-domain antibody, wherein the CDR of the VHH chain includes the following: CDR1 with an amino acid sequence as shown in SEQ ID NO:5n+1; CDR2 with an amino acid sequence as shown in SEQ ID NO:5n+2, or CDR2 with an amino acid sequence having an sequence identity of greater than 85% with a sequence as shown in SEQ ID NO:2; and CDR3 with an amino acid sequence as shown in SEQ ID NO: 5n+3; wherein, each n is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15.

Anti-PD-L1 single-domain antibody and derivatives and use thereof

Gateway device

Water leak detector

Combined lamp and lamp base

Lamp

The present invention relates to the field of biomedicine and specifically relates to an anti-VEGF-anti-PD-L1 bispecific antibody, a pharmaceutical composition of same, and uses thereof. Specifically, the present invention relates to the bispecific antibody, which comprises: a VEGF-targeted first protein functional area and a PD-L1-targeted second protein functional area, wherein: the first protein functional area is an anti-VEGF antibody or an antigen-binding fragment thereof, or, the first protein functional area comprises a VEGF receptor or a fragment having a VEGF receptor function, and the second protein functional area is an anti-PD-L1 monoclonal antibody. The bispecific antibody of the present invention is capable of activating the immune system and blocking tumor angiogenesis at the same time, and provides great antitumor prospects.

Anti-VEGF-anti-PD-L1 bispecific antibody, pharmaceutical composition of same, and uses thereof

Growing community of inventors

Guangdong, China

Weifeng Huang