Biosteed Gene Expression Tech. Co., Ltd.

Weidong Zhou

Li Sun

Qingjiang Xiao

Fenghong Yin

Tiebing Wang

Bin Liu

Yong Zhang

Lu Zhuang

Min Liu

Ping Zhang

Huihuang Lin

Defang Zhang

Lishan Yang

Shiye Shen

Song Lin

Qingsong Lu

Linzhong Zhang

Xiaojin Liao

Lifang Lei

Shihong Luo

Tianle Xu

The growth hormone with high biological activity modified by the double-stranded polyethylene glycol at a single site and the preparation method thereof are provided. The PEGylated growth hormone has a higher biological activity and a longer half-life than the unmodified growth hormone. The composition comprising the PEGylated growth hormone is useful in the treatment of the growth or development disorder such as growth hormone deficiency, Turner syndrome etc.

Double-stranded polyethylene glycol modified growth hormone, preparation method and application thereof

The present invention relates to interferon-&#x3b1;2b modified with Y-shaped branched polyethylene glycol (PEG) at a single Lys residue and the preparation thereof. The peglated IFN-&#x3b1;2b can be used for the preparation of a medicament for treating a disease, e.g. viral infections such as Hepatitis C.

Interferon alpha-2B modified by polyethylene glycol and methods of preparation thereof

The present invention relates to interferon (IFN)-&#x3b1;2a modified at a specific Lys residue with Y-shaped branched polyethylene glycol (PEG) derivative and the preparation thereof, as well as the use of the prepared IFN-&#x3b1;2a modified by PEG at a single amino acid residue in medicines.

Interferon alpha-2a modified by polyethylene glycol and methods of preparation thereof

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Xiamen, China

Weidong Zhou