Janssen Pharmaceutica Nv

Janssen Pharmaceuticals, Inc.

Cellzome Limited

Wei Zhuang

Gregor James MacDonald

Johannes Wilhelmus John F Thuring

Johannes Wilhelmus Thuring

Yves Emiel Maria Van Roosbroeck

Marcel Frans Leopold De Bruyn

Frans Alfons Maria Van Den Keybus

Anne Simone Josephine Lesage

Theodorus Dinklo

Anne Simone Lesage

Gregor James Macdonald

Frans Alfons Van Den Keybus

Yves Emiel Van Roosbroeck

Marcel Frans De Bruyn

Henricus Jacobus Maria Gijsen

Sven Franciscus Anna Van Brandt

Didier Jean-Claude Berthelot

Michel Anna Jozef De Cleyn

Daniel Oehlrich

François Paul Bischoff

Michel Surkyn

Mirko Zaja

James Edward Stewart Duffy

Pauline Carol Stanislawski

James Edward Duffy

The present invention relates to 1-aryl-3-aniline-5-alkyl-1,2,4-triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to potent positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

Trisubstituted 1,2,4 triazoles

The present invention relates to 1-alkyl-3-aniline-5-aryl-pyrazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

Trisubstituted pyrazoles as acetylcholine receptor modulators

The present invention is concerned with novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives of Formula (I) wherein R, R, R, R, X, A, A, A, A, Y, Y, Yand Z have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators

The present invention relates to substituted 1-(alkyl)-3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I).  The invention particularly relates to potent positive allosteric modulators of nicotinic acetylcholine receptors which have the capability of increasing the efficacy of nicotinic receptor agonists.

The present invention relates to 3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I).  The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

Trisubstituted 1,2,4-triazoles

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Antwerp, Belgium

Wei Zhuang