Bayer Animal Health Gmbh

Elanco Animal Health Gmbh

Bayal Animal Health Gmbh

Wei Zhuang

Hans-Georg Schwarz

Nils Griebenow

Daniel Kulke

Walter Hübsch

Adeline Köhler

Thomas Simon Ilg

Ulrich Görgens

Claudia Böhm

Johannes Köbberling

Claudia Welz

Kirsten Börngen

Bernd Alig

Iring Heisler

Maike Hink

Niels Lindner

Walter Huebsch

Werner Hallenbach

Ulrich Ebbinghaus-Kintscher

Martin Adamczewski

Klaus Raming

Adeline Koehler

Kirsten Boerngen

Nils Griebnow

Isa Jana Irina Janssen

Claudia Boehm

Dirk Nennstiel

Johannes Kobberling

Claudia Bohm

Walter Hubsch

Adeline Kohler

Kirsten Borngen

Adeline KÖHLER

The present invention relates to novel compounds of general formula (I): withA being A1 or A: andin which T, X, Y, Ro, R, Rand Rare as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Anthelmintic compounds

The present invention covers new isoquinoline compounds of general formula (I): in which A, R, R, R, R, R, R, and Q are as defined herein, methods of preparing the compounds, intermediate compounds useful for preparing the compounds of formula (I), pharmaceutical compositions and combinations comprising the compounds of formula (I) and the use of the compounds of formula (D) for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Isoquinoline derivatives and their use for the treatment of parasitic infections

The present invention covers new quinoline compounds of general formula (I), in which A, R, R, R, R, R, R, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

Quinoline derivatives

The present invention covers new quinoline compounds of general formula (I): in which A, R, R, R, R, R, R, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Anthelmintic quinoline-3-carboxamide derivatives

The present invention covers azaquinoline compounds of general formula (I), with A being (A1) or (A2), and in which T, R, R, R, R, R, Rand Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

Azaquinoline derivatives

The present invention covers quinoline compounds of general formula (I), in which A, R, R, R, R, R, R, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

Quinoline derivatives for treating infections with helminths

The present invention covers bicyclic pyrazole compounds of general formula (I): in which G, A, R, R, R, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

Bicyclic pyrazole derivatives

The present invention covers Pyrazolopyrimidine compounds of general formula (I): in which n, o, X, Y, R, Q, R, R, Rand Rare as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Pyrazolopyrimidine derivatives

The present invention covers new quinoline compounds of general formula (I) in which A, R, R, R, R, R, R, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R, R, Rand Rare as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

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Monheim, Germany

Wei Zhuang