Lonza Ag

Withyou Biotechnology Co., Ltd.

Geneheal Biotechnology Co., Ltd.

Lonza Guangzhou Research & Development Center Ltd

Wei Zhu

Wilhelm Quittmann

Wuguang Pan

Rongmin Chen

Feng Ye

Xionglei He

An application of dipeptide as an ACE enzyme activity inhibitor. Virtual screening is performed on 400 types of dipeptide based on ACE inhibiting effects thereof according to a detected ACE enzyme crystal structure by using self-developed software and adopting a molecular docking method, experiments are conducted to verify the ACE inhibitory activity of the dipeptide obtained by virtual screening, and it finds out that the dipeptide with the N terminal as cysteine has better ACE inhibitory activity.

Application of dipeptide as ace enzyme activity inhibitor

Method of synthesizing a compound of formula (I), wherein R1, R2 are, independently, chloro or fluoro, and wherein R3 is H, alkyl, aralkyl or is an alkylether or alkylthioether comprising the steps of firstly reducing a diazeny compound of formula (II) non-catalytically or with a catalytic amount of an homogenous organic, non-metal catalyst to the corresponding hydrazo compound of formula (III) and in a second step catalytically hydrogenating said hydrazo compound in with a heterogeneous Ni-catalyst to the compound of formula (I). 

Reduction of 5-(aryl-diazenyl)-4,6-dihalo-pyrimidine

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Guangzhou, China

Wei Zhu