Sichuan Kelun-biotech Biopharmaceutical Co., Ltd.

Chinese Academy of Sciences

Sichuan Keiun-biotech Biopharmaceutical Co., Ltd.

Wei Zhong

Jingyi Wang

Lichun Wang

Hong Zeng

Mingliang Zhao

Jiaqiang Cai

Qiang Tian

Hongmei Song

Donghai Su

Haitao Huang

Yuting Tan

Xin Zhou

Hua Deng

Nan Yu

Tao Wang

Xiaoqing Chen

Shuai Song

Yong You

Jiangang Chen

Guoqing Zhong

Yao Liu

Wanyu Zhao

Yongyong Wu

Yuhua Zou

Yan Qing

Yongjia Hao

Shaohua Li

Xunwei Wu

Fenghuan Su

Gang Liu

Donghong Li

Wenjia Li

Hong Ye

Yitao Zhang

Lei Wu

Long Yang

Canopy pole

The invention relates to a polyamide compound and a use thereof. Specifically, the invention relates to a type of polyamide compound (which preferably comprise one or more amide bonds formed by condensation of same or different L-amino acids or D-amino acids), or stereoisomers, crystalline polymorphs, solvates, metabolites, prodrugs or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with &#x3ba;-opioid receptor. The polyamide compound of the invention has excellent &#x3ba;-opioid receptor agonistic activity and hydrophilicity, thus having a lesser ability of penetrating the blood-brain barrier and a lower capacity for entering the brain. The compound of the invention has higher selectivity for a &#x3ba;-opioid receptor, lower addictiveness, improved pharmacokinetic properties, and improved safety (lower toxicity and/or fewer side effects), good patient compliance, and/or lesser propensity for developing tolerance, among other excellent medicinal properties.

Polyamide compound and use thereof

Provided in the present invention are a compound of Formula (I), a pharmaceutical composition comprising the same, a method for preparing the same, and use thereof as a NS5B polymerase inhibitor, a DNA polymerase inhibitor or a reverse transcriptase inhibitor for the prevention or treatment of viral diseases or cancers.

Nucleoside phosphate compound and preparation method and use thereof

The present invention relates to a novel compound of 4'-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same and an application thereof. Specifically, the present invention relates to a phosphamide derivative of 4&#x2032;-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same, a use thereof in the preparation of a medicine for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases, and a method of using the same for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases.

Compound of 4'-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof

A method of designing a box-type energy-dissipating section of a box-type energy-dissipating mudflow diversion flume. Firstly, the longitudinal gradient J of the flume and the roughness coefficient n 0 of a fully-lined flume bottom () are determined. Then, the parameters of the box-type energy-dissipating section are set, and related parameters are substituted into a formula for calculation, so that the overall roughness coefficient n of the flume is obtained. Further, the flow velocity of the mudflow is calculated by means of the Manning formula. Finally, the flow velocity of the mudflow is compared with the non-scouring and non-silting velocity allowed by the flume, and the design value of the box-type energy-dissipating section is obtained through final optimization. The method factors in the longitudinal gradient J of the flume, the length L of the box-type energy-dissipating section, the width b of the box-type energy-dissipating section, and the average diameter D of filler stones. With the method, the overall roughness coefficient n of the flume under different design conditions can be determined reasonably, so as to further implement the optimized design of the box-type energy-dissipating section of the box-type energy-dissipating mudflow flume. Further provided is an application of the method of designing a box-type energy-dissipating section of a box-type energy-dissipating mudflow flume.

Method of designing box-type energy-dissipating section of box-type energy-dissipating mudflow diversion flume, and application

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Sichuan, China

Wei Zhong