Sichuan Haisco Pharmaceutical Co., Ltd.

Vertechs Oil & Gas Technology Co., Ltd.

Vertechs Petroleum Technology Innovation & Equipment Manufacturing Co., Ltd

Jumbo Drug Bank Co., Ltd.

Huawei Technologies Co., Limited

Beijing Friendship Hospital, Capital Medical University

Wei Zheng

Pengfei Zhao

Qijun Zeng

Chen Zhang

Zhenchang Wang

Yawen Liu

Tingting Zhang

Pengling Ren

Han Lv

Hongxia Yin

Linkun Cai

Dehong Luo

Erwei Zhao

Runqing Bai

Chen Liang

Jing Li

Dong Liu

Shuhui Chen

Jian Li

Wei Jun Zhang

Guoping Hu

Chengde Wu

Lingyun Wu

Lele Zhao

Chunli Shen

Fei Ye

Yonggang Wei

Pangke Yan

Xiawei Wei

Jianmin Wang

XiaWei Wei

Ning Jiang

Zhenggang Huang

Jiaqiang Yu

Peng Yang

Chengsong Qiu

Yong Yang

Anbang Huang

Longbin Huang

Fubo Liang

Weijiang Qian

Saisai Ni

Dan Jin

Xichao Zhou

Zhiwei Wen

Liangliang An

Weizhou Wang

Xushan Han

Xiaomin Zhang

Chao Ma

Disclosed are a class of BTK kinase inhibitor compounds with a high activity and a high selectivity and the use thereof in the preparation of a drug for treating BTK target-related diseases. Specifically, disclosed are a compound shown as formula (I), and an isomer and a pharmaceutically acceptable salt thereof.

Substituted pyrazlo[3,4-c]pyridines as selective BTK kinase inhibitors

An ultra-high expansion downhole packer includes an anchor, a primary expansion cone, and a central tube. The anchor is provided with a first tapered through-hole having a large end sleeved at a small end of the primary expansion cone. The anchor is radially expandable to anchor with an inner wall of a wellbore. The primary expansion cone is provided with a second tapered through-hole, and the second tapered through-hole has a large end sleeved at a small end of the central tube. The primary expansion cone is a radially expandable structure, and the primary expansion cone supports the anchor after an expansion. The primary expansion cone is provided between the anchor and the central tube. The primary expansion cone is first driven into the anchor to make the anchor radially expand, and then the central tube is driven into the primary expansion cone to make the anchor radially expand again.

Ultra-high expansion downhole packer

A spiral deployed isolation tool includes a central pipe having an outer surface in a conical shape and an axial through hole, and an anchoring sealing structure. The anchoring sealing structure is matched and sleeved on the outer surface of the central pipe. The anchoring sealing structure has a first sealing section and an anchoring section. The first sealing section is located at a larger end of the central pipe. The anchoring section includes a plurality of slips, the first sealing section includes a plurality of first spiral sealing rings. The plurality of slipscorrespond to the plurality of first spiral sealing rings one by one to respectively form an integral structure. The plurality of slips are uniformly expanded in a radial direction, thereby achieving uniform circumferential distribution of slips, so that the slips are evenly anchored on an inner wall of the whole wellbore.

Spiral deployed isolation tool

The invention provides a peptide amide compound represented by the general general formula (I), a preparation method thereof, and a medical application thereof. The compound has a novel structure, better biological activity, and better analgesic effect. 

Peptide amide compound and preparation method and medical use thereof

Growing community of inventors

Chengdu, China

Wei Zheng