The United States of America, as Represented by the Secretary, Department of Health and Human Services

The University of North Carolina at Chapel Hill

Wei Zhao

Li Liu

Xiaodong Wang

Anton Simeonov

Ajit Jadhav

Min Shen

Matthew E Hall

Matthew Brian Boxer

Kyle Ryan Brimacombe

Andrew Louis McIver

Jason Matthew Rohde

Mindy Irene Emily Davis

Rajan Pragani

Natalia Martinez

Surendra Karavadhi

Yuhong Fang

Matthew Hall

A compound of Formula II or a pharmaceutically acceptable salt thereof, wherein CyN is a cyclic amine group bound via a nitrogen atom; X is C or N; Rand Rare each independently a halogen, CN, CF, CHF, CHF, a C-C10alkyl group, a C1-Calkoxy group, a di(C-Calkyl)amino; m and n are each independently 1, 2, or 3, and represents either a single bond or a double bond, wherein the racemic mixture of 3-(4-(4-chlorophenyl)thiazol-2-yl)-1-(2-ethyl-5-methoxyphenyl)-6-(2-methylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridin-2(1H)-one atropisomers is excluded.

Thiazole derivatives useful as mutant IDH1 inhibitors for treating cancer

Growing community of inventors

Rockville, MD, United States of America

Wei Zhao