Astrazeneca Ab

Shanghai Jiao Tong University

Hutchison Medipharma Limited

Sph No. 1 Biochemical & Pharmaceutical Co., Ltd.

Zhejiang Geely Holding Group Co., Ltd

Shanghai Pulse Medical Technology, Inc.

Shanghai Maple Guorun Automobile Co.

Shanghai Genon Biological Product Co., Ltd.

Shanghai Ghrepower Green Energy Co., Ltd.

Shanghai Maple Automobile Co., Ltd

Wei Yu

Jun Zhang

Jing Li

Shufu Li

Liang Wu

Feng Gao

Tong Zhang

Bin Dong

Shengxian Tu

Andrew Turner

Bo Liu

Yong Feng Pan

Wanbin Zhang

Su Zhang

Zhenfeng Zhang

Jiayue Huang

Keith Raymond Mulholland

Zhenping Tian

Jian Yang

Xiaogang Fu

Guoxiang Cheng

Yundai Chen

Kaibao Xiong

Yujia Fu

Yuanlin Wang

Yaohua Zhang

Ximing Jiang

Qisun Gong

Neil Keith Adlington

Malcolm Allan Young Gall

Gareth Paul Howell

Fuhua Yan

Guoyong Jiang

Daming Zhu

Minggang Liu

Zhongwei Zhang

Haisheng Yu

Andrew Roy Turner

Andrew Timothy Turner

Yusheng Ye

This specification generally relates to an improved method for the manufacture of 3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine (I), or pharmaceutically acceptable salts thereof; polymorphic forms thereof, and intermediates useful in the manufacture of such compounds and salts thereof.

Method for the manufacture of 3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine and polymorphic forms thereof

A low-temperature continuous-flow preparation method of bedaquiline includes the following steps. (a) A first feed liquid and a second feed liquid are subjected to a first continuous flow reaction for 30-600 seconds to obtain a first reaction mixture. (b) The first reaction mixture and a third feed liquid are subjected to a second continuous flow reaction for 30-600 seconds to obtain a second reaction mixture. (c) The second reaction mixture was quenched to afford bedaquiline.

Low-temperature continuous-flow preparation method of bedaquiline

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Wei Yu