Industrial Technology Research Institute

Bio Preventive Medicine Corp.

Wei-Ya Lin

Tzu-Ling Tseng

Ping-Fu Cheng

Hung-Yi Li

Tsai-Wei Hsu

Yi-Ting Chen

Yen-Peng Li

Mary Ya-Ping Yeh

Yuh-Feng Ling

Jin-Shuen Chen

Ching-Fang Lu

Yi-Chen Liu

Angelina Huai-Lo Lee

Hong-Zen Yeh

Chwei-Shiun Yang

Giien-Shuen Chen

Yuh-Feng Lin

Described is a method of detecting a protein fragment in a urine sample and a serum sample. The protein fragment is a urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, or serum osteopontin fragment. The urine sample and the serum sample are obtained from the same individual.

Method of detecting a urine protein fragment and a serum protein fragment

Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and &#x3b2;-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing and staging liver fibrosis.

Biomarkers useful in liver fibrosis diagnosis

Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and &#x3b2;-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis.

Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.

Biomarkers associated with nephropathy

Disclosed is use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.

Urine and serum biomarkers associated with diabetic nephropathy

Growing community of inventors

Dali, Taiwan

Wei-Ya Lin