Amo Wavefront Sciences, LLC

The University of Texas System

Amo Development, LLC

Wei Xiong

Thomas Daniel Raymond

Stephen W Farrer

Daniel Ralph Neal

Richard James Copland

Carmen Canovas Vidal

Daniel Richard Hamrick

Paul D Pulaski

Zhiqiang An

Ningyan Zhang

Jean X Jiang

John G Dixson

Sumin Gu

James Copland

Manuel A Riquelme

Mi Deng

Chengcheng Zhang

Xun Gui

Junke Zheng

Naomi Ledene Sayre

Pablo Artal

Jason Hoy

Paul Pulaski

John Grant Dixson

Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening are provided.

Methods of treating metastasis, including inhibiting bone cancer metastasis, by administering an antibody which binds connexin 43 (Cx43) hemichannel

An optical measurement system and apparatus for carrying out cataract diagnostics in an eye of a patient includes a Corneal Topography Subsystem, a wavefront aberrometer subsystem, and an eye structure imaging subsystem, wherein the subsystems have a shared optical axis, and each subsystem is operatively coupled to the others via a controller. The eye structure imaging subsystem is preferably a fourierdomain optical coherence tomographer, and more preferably, a swept source OCT.

Optical imaging and measurement systems and methods for cataract surgery and treatment planning

The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.

Anti-LILRB antibodies and their use in detecting and treating cancer

Methods of treating an osteolytic tumor and spinal cord injury by administering connexin (Cx) 43 hemichannel-binding antibodies

An optical measurement instrument performs a series of wavefront measurements to obtain a plurality of sets of wavefront aberrometry data for an eye, and performs a series of corneal topography measurements to obtain a plurality of sets of corneal topography data for the eye. Each set of wavefront aberrometry data is obtained at a corresponding different point in time, and each set of corneal topography data is obtained at a corresponding different point in time. The wavefront aberrometry data and the corneal topography data are processed to produce combined tear film breakup data as a function of time. The combined tear film breakup data may be employed as a metric for evaluating a level of tear film breakup of the eye as a function of time.

Method and system for dynamically measuring tear film breakup and irregularity using corneal topography and wavefront aberrometry

Improved devices, systems, and methods for planning cataract surgery on an eye of a patient incorporate results of prior corrective surgeries into a planned cataract surgery of a particular patient by driving an effective surgery vector function based on data from the prior corrective surgeries. The exemplary effective surgery vector employs an influence matrix which may allow improved refractive corrections to be generated so as to increase the overall efficacy of a cataract surgery by specifying one or more parameters of an intraocular lens (IOL) to be implanted during the cataract surgery.

Method and system for eye measurements and cataract surgery planning using vector function derived from prior surgeries

A system for predicting optical power for an intraocular lens based upon measured biometric parameters in a patient's eye includes: a biometric reader capable of measuring one or more biometric parameters of the patient's eye and obtaining at least one value for at least one of the one or more biometric parameters, and further measuring a representation of a corneal topography of the patient's eye; a processor; and a computer readable medium coupled to the processor and having stored thereon a program that upon execution causes the processor to: receive the at least one value; obtain a corneal spherical aberration (SA) based upon the representation of the corneal topography; and calculate an optimized optical power to obtain a desired postoperative condition by applying the received at least one value and the obtained corneal spherical aberration to a modified regression.

Apparatus, system, and method for intraocular lens power calculation using a regression formula incorporating corneal spherical aberration

A system includes a model eye and an optical measurement instrument, which includes: a corneal topography subsystem; a wavefront sensor subsystem; and an eye structure imaging subsystem. The subsystems may have a common fixation axis, and be operatively coupled to each other via a controller. The optical measurement instrument may perform measurements of the model eye to verify correct operation of the optical measurement instrument for measuring one or more characteristics of a subject's eye. The model eye may include an optically transmissive structure having a front curved surface and an opposite rear planar surface, and a material structure provided at the rear planar surface of the optically transmissive structure and having a characteristic to cause a speckle pattern of a portion of a coherent light beam that is directed back out the front curved surface of the optically transmissive structure to have a bright-to-dark ratio of less than 2:1.

Model eye producing a speckle pattern having a reduced bright-to-dark ratio for use with optical measurement system for cataract diagnostics

An algorithm locates valid light spots produced on an image detector by a wavefront of interest. The algorithm includes sequentially examining pixels of the image detector to determine for each of the pixels whether the light intensity detected by the pixel is greater than a threshold, When the pixel's detected light intensity is determined to be greater than the threshold, the algorithm includes: determining whether the pixel belongs to a valid light spot; and when the pixel is determined to belong to a valid light spot; saving data indicating a location for the valid light spot; and masking out a group of pixels of the image detector at the determined location such that the masked pixels are considered to have a light intensity less than the threshold for a remainder of the sequential examination.

Method of locating valid light spots for optical measurement and optical measurement instrument employing method of locating valid light spots

A system for determining a surface shape of a test object includes a pattern having a plurality of first elements dispose about a central axis and defining an aperture containing the central axis. The first elements includes a plurality of common elements having a common form and a reference element having a reference form that is different than the common form. The system further comprises a detector array and an optical system. The optical system is adapted to provide an image of the first elements when light reflects off a surface of a test object, passes through the aperture, and is received by the detector array. The reference form may be configured to facilitate an association between the common elements and the spot images of the common elements.

Systems and methods for measuring surface shape

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Albuquerque, NM, United States of America

Wei Xiong