Pacific Industrial Development Corporation

Children's National Medical Center

Oncoimmune, Inc.

Oncoc4, Inc.

Oncolmmune, Inc.

Chemano, Inc.

Chemnano, Inc.

Wei Wu

Jeffery Lachapelle

Yunkui Li

David Shepard

Yang Liu

Pan Zheng

Anatoly Bortun

Xincheng Zheng

De Gao

Martin Devenport

Mingyue Liu

Mila Bortun

Fei Tang

Jin Cho

Xuexiang Du

Geng Zhang

Manjola Mancka

Bing Tan

Nicholas Goodman

John Novak

Christopher Sketch

Evan Leonard

William Germond

Ashwin Sankaran

Yuhao Liao

Andrew Rajewski

Christopher Zyskowski

Jessica Brown

Jeffrey Lachapelle

Nick Goodman

A method for preparing high nickel lithiated metal oxides that includes selecting one or more nickel precursors; at least one non-corrosive lithium salt; and a plurality of metal oxide or hydroxide precursors. The metal precursors and lithium salts are mixed together to form a mixture comprising:LiNiMNOFa  (F-1)wherein x=1.0-1.1, 0.80≤y≤0.90, 0.03<z≤0.15, and 0≤a≤0.05; M is Co or Fe; and N is Al, Mn, Fe, Ca, Mg, Ti, Cr, Nb, Mo, W, B, or a mixture thereof provided N may be Fe when M is Co. The mixture is subjected to sintering (1st step) in air at ≥750° C. to form a powder. The powder is subjected to a 2sintering step in Oat ≤750° C. to form the high nickel lithiated metal oxides.

Method for producing high nickel lithiated metal oxide for battery

This invention relates to CTLA-4 protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy.

CD80 and CD86 binding protein compositions and uses thereof

An apparatus, system, and method for removing impurities from a non-aqueous electrolyte used in an electrochemical cell. The apparatus includes a vessel having one or more chambers with an inlet and an outlet configured to allow the flow of the electrolyte through the one or more chambers; and an inorganic scavenging agent located within the one or more chambers. The inorganic scavenging agent includes one or more types of zeolite particles, at least one type of absorbent filler particles, or a combination of the zeolite and absorbent filler particles. The inorganic scavenging agent absorbs one or more of moisture, free transition metal ions, or hydrogen fluoride (HF) that is present as impurities in the non-aqueous electrolyte.

Electrolyte treatment system and method

A method of forming AEI-type zeolites in a hydrothermal synthesis without the use of hydrogen fluoride (HF) and in the presence of an FAU zeolite NaY with SAR ≤5, a Y zeolite with a SAR ≥5, or a combination thereof. A gel composition formed upon using this method includes one or more sources of silica, alumina, organic structure directing agents (OSDA), and alkali metal ions; zeolite seeds; and water. This gel composition is defined by the molar ratios of: SiO/AIO18:1 to 100:1; MO/SiO0.15:1 to 0.30:1; ROH/SiO0.05:1 to 0.13:1; and HO/SiO5:1 to 20:1; wherein M is the alkali metal ion and R is an organic moiety derived from the OSDA. This gel composition, after reacting at a temperature between 135° C. to about 200° C. for 10 hours to 168 hours forms the crystalline AEI-type zeolite having a silica to alumina ratio (SiO:AIO) that is greater than 15:1.

Method of making AEI-type zeolites having a high silica to alumina molar ratio (SAR)

A nanocrystal-sized cerium-zirconium mixed oxide material includes at least 30% by mass zirconium oxide; between 5% to 55% by mass cerium oxide; and a total of 25% or less by mass of at least one oxide of a rare earth metal selected from the group of lanthanum, neodymium, praseodymium, or yttrium. The nanocrystal-sized cerium-zirconium mixed oxide exhibits hierarchically ordered aggregates having a dparticle size less than 1.5 μm and a total pore volume after calcination at a temperature of 600° C. or more that is at least 0.7 cm/g with a fraction of pores between 2 nm to 10 nm being less than 15%. The nanocrystal-sized cerium-zirconium mixed oxide material is prepared using a co-precipitation method followed by milling the dried and calcined oxide material. The nanocrystal-sized cerium-zirconium mixed oxide material forms a particulate filter that may be used in an exhaust system arising from a gas or diesel engine.

Nanocrystal-sized cerium-zirconium oxide material and method of making the same

A method of forming an AEI-type zeolite in a hydrothermal synthesis without the use of hydrogen fluoride (HF) and in the absence of any FAU zeolite Y. A gel composition formed upon using this method includes one or more sources of silica; one or more sources of alumina, one or more organic structure directing agents (OSDA); a source of alkali metal ions; and water. This gel composition is defined by the molar ratios of: SiO/AIO16:1 to 100:1; MO/SiO0.15:1 to 0.30:1; ROH/SiO0.05:1 to 0.20:1; and HO/SiO5:1 to 20:1; wherein M is the alkali metal ion and R is an organic moiety derived from the OSDA. This gel composition, after reacting at a temperature between 135° C. to about 180° C. for 15 hours to 168 hours forms the crystalline AEI-type zeolite having a silica to alumina ratio (SiO:AIO) that is greater than 8:1.

Method of making AEI-type zeolites having a high silica to alumina ratio (SAR)

A method of forming an AFX zeolite in a hydrothermal synthesis that exhibits a silica to alumina (SiOAIO) molar ratio (SAR) that is between 8:1 and 26:1; has a morphology that includes one or more of cubic, spheroidal, or rhombic particles with a crystal size that is in the range of about 0.1 micrometer (μm) to 10 μm. This AFX zeolite also exhibits a Brönsted acidity that is in the range of 1.2 mmol/g to 3.6 mmol/g as measured by ammonia temperature programmed desorption. A catalyst formed by substituting a metal into the framework of the zeolite exhibits about a 100% conversion of NO emissions over the temperature range of 300° C. to 650° C.

Method of making AFX zeolites having high thermal stability

A method of forming an SSZ-13 zeolite in a hydrothermal synthesis yields an SSZ-13 zeolite that exhibits a silica to alumina (SiO:AlO) molar ratio (SAR) that is less than 16:1; has a morphology that includes one or more of cubic, spheroidal, or rhombic particles with a crystal size that is in the range of about 0.1 micrometer (μm) to 10 μm. This SSZ-13 also exhibits a Brönsted acidity that is in the range of 2.0 mmol/g to 3.4 mmol/g as measured by ammonia temperature programmed desorption. A catalyst formed by substituting a metal into the framework of the zeolite provides for low temperature light-off of the NOx conversion reactions, while maintaining substantial performance at higher temperatures demonstrating hydrothermal stability.

Method of making SSZ-13 zeolites with high acidity and low silica to alumina ratio (SAR)

A method of making an oxygen storage material (OSM) with developed mesoporosity having a small fraction of pores &#x3c;10 nm (fresh or aged), and resistance to thermal sintering is provided. This OSM is suitable for use as a catalyst and catalyst support. The method of making this oxygen storage material (OSM) includes the preparation of a solution containing pre-polymerized zirconium oligomers, cerium, rare earth and transition metal salts; the interaction of this solution with a complexing agent that has an affinity towards zirconium; the formation of a zirconium-based precursor; and the co-precipitation of all constituent metal hydroxide with abase.

Method of making mesoporous oxygen storage materials for exhaust gas treatment; said oxygen storage materials and their use

This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.

An oxygen storage material (OSM) that exhibits enhanced redox properties, developed mesoporosity, and a resistance to sintering. The oxygen storage material (OSM) has a high oxygen storage capacity (i.e., OSC&#x3e;1.5 mmol H/g) and enhanced reducibility (i.e., bimodal TPR-Hprofile with two Tin the temperature range from 150&#xb0; C. to 550&#xb0; C.). The OSM is suitable for use as a catalyst and a catalyst support. The method of making the oxygen storage material comprises the preparation of a solution containing zirconium, cerium, rare earth and transition metal salts, followed by the co-precipitation of all constituent metal hydroxides with a base.

Catalyst comprising ceria-zirconia-oxygen storage material and process for its production

Mesoporous, zirconium-based mixed oxides and a method of making the same comprises: injecting a polyvalent metal-containing solution into an electrolyte solution to form a mother liquor; forming a precipitate; aging the precipitate in the mother liquor to form the mixed oxides; washing the mixed oxides with an aqueous medium; drying and collecting the mixed oxides. The pH of the electrolyte solution exceeds the isoelectric point for zirconium-based mixed oxides. The mixed oxides exhibit a single particle size distribution, improved Ce02 reducibility in the presence of Rhodium, a decrease in surface area after calcination (800-1100&#xb0; C.) that is not more than 55%, and a tetragonal/cubic structure after calcination. After calcination at 1100&#xb0; C. for 10 hours in air, the mixed oxides exhibit a surface area &#x3e;25 m2/g, a pore volume &#x3e;0.20 cm3/g, an average pore size &#x3e;30 nm, and an average crystallite size between 8-15 nm.

Method of making mesoporous zirconium-based mixed oxides

Provided herein is a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a mammalian immunoglobulin.

Methods of use of soluble CD24 for therapy of rheumatoid arthritis

An inorganic oxide material doped with nano-rare earth oxide particles that is capable of trapping one or more of NOor SOat a temperature that is less than 400&#xb0; C. The nano-rare earth oxide particles have a particle size that is less than 10 nanometers. The catalyst support can trap at least 0.5% NOat a temperature less than 350&#xb0; C. and/or at least 0.4% SOat a temperature less than 325&#xb0; C. The catalyst support can trap at least 0.5% NOand/or at least 0.2% SOat a temperature that is less than 250&#xb0; C. after being aged at 800&#xb0; C. for 16 hours in a 10% steam environment. The catalyst support exhibits at least a 25% increase in capacity for at least one of NOor SOtrapping at a temperature that is less than 400&#xb0; C. when compared to a conventional rare earth doped support in a 10% steam environment.

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Ann Arbor, MI, United States of America

Wei Wu