Triastek, Inc.

Gy Bio-materials Co., Ltd.

Wei Wu

Xiaoling Li

Senping Cheng

Haili Liu

Feihuang Deng

Renjie Li

Haohui Lu

Yang Liu

Hui Zhou Lin

Juan Yao

Xiaofei Wang

Sicong Lin

The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.

High-throughput and high-precision pharmaceutical additive manufacturing system

Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.

Precision pharmaceutical 3D printing device

A 3D printing device (), comprising a melt extrusion module (), a printing module (), and a platform module (). The melt extrusion module () comprises a processing chamber () consisting of a feed inlet () and a discharge outlet (), as well as an extrusion means () and a heating means () disposed at the processing chamber; the melt extrusion module () is configured to receive an initial material from the feed inlet () of the processing chamber (), and heat and extrude the initial material to convert the initial material into a molten body, which is extruded out of the discharge outlet () of the processing chamber (). The printing module () is communicated with the discharge outlet () of the processing chamber () and is provided with a nozzle (); the printing module () is configured to receive the molten body extruded from the discharge outlet () of the processing chamber () and guide the molten body to be extruded out of the nozzle (). The platform module () is configured to receive the molten body extruded from the nozzle ().

3D printing device and method

A bondable blood-friendly polymer is a terpolymer or a quadripolymer at least formed by polyethylene glycol alkyl ether acrylate or polyethylene glycol alkyl ether methacrylate (I), and zwitterionic acrylic ester or zwitterionic methacrylic ester (II), and acrylic acid or a methacrylate derivative with an epoxypropyl group, an isocyanate group, a trialkoxy silane, a hydroxyalkyl group, a propargyl group or a quaternary ammonium group (III). In the present invention, the blood-friendly polymer with a potentially-bondable group has the following advantages: although the water insolubility thereof is implemented by using the hydrophobicity physical effect of an existing higher alkyl acrylate linkage, the blood friendliness of a coating is reduced due to the existence of a great number of hydrophobic chain links in the polymer; and a physical coating is slowly desolventized from the surface to be ablated in the application process of the physical coating. A disclosed bondable blood-friendly polymer coating not only can overcome these defects, but also can improve the blending property thereof. Disclosed are composition, a structure and a preparation method of the bondable blood-friendly polymer.

Bondable blood-friendly polymer and preparing method thereof

Growing community of inventors

Nanjing, China

Wei Wu