Baylor College of Medicine

Perkinelmer Las, Inc.

Spectral Genomics, Inc.

Seqwright, Inc.

Wei-Wen Cai

Allan Bradley

Upendra K Marathi

Mansoor S Mohammed

Shishir Shah

Richard Gibbs

Jason Kang

In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or prognosis of syndromes associated with a contiguous gene abnormality. Kits are also provided.

Compilations of nucleic acids and arrays and methods of using them

The invention provides biological molecules modified by reaction with a compound having the formula: R&#x2014;X&#x2014;R, wherein Ris a cyclic ether group or an amino group, Ris an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to the alkoxysilane group. The invention also provides arrays, or 'biochips,' comprising these modified biological molecules. Also provided are methods for making and using these compositions.

Articles of manufacture and methods for array based analysis of biological molecules

A simplified strategy for sequencing large genomes has been developed. Clone-Array Pooled Shotgun Sequencing (CAPSS) is based upon pooling rows and columns of arrayed genomic clones, for shotgun library construction. Random sequences are accumulated and the data are assembled by sequential comparison of rows and columns, to resolve the sequence of clones at points of intersection. Compared to either a clone-by-clone approach or whole genome shotgun sequencing, CAPSS requires relatively few library constructions and only minimal computational power for a complete genome assembly. The strategy is suitable for sequencing large genomes for which there are no sequence-ready maps, but for which relatively high resolution STS maps and highly redundant BAC libraries are available. It is immediately applicable to the sequencing of mouse, rat, zebra fish and other important genomes, and can be managed in a cooperative fashion to take advantage of the distributed international DNA sequencing capacity.

Clone-array pooled shotgun strategy for nucleic acid sequencing

The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid supports, for instance, a glass surface, without first derivatizing the glass surface. High-density microarrays based on these modified molecules as well as methods for preparing these microarrays are also useful.

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Pearland, TX, United States of America

Wei-Wen Cai