Guangzhou Construction Engineering Co., Ltd

Chinese Academy of Sciences

Coupang, Corporation

L'oreal

Other

International Business Machines Corporation

Huawei Technologies Co., Limited

Alcatel Lucent

Shanghai Micro Electronics Equipment (Group) Co., Ltd.

Medshine Discovery Inc.

Cas Center for Excellence in Molecular Plant Sciences

Zhe Jiang Medicine Co., Ltd

Merck Sharp + Dohme Corp.

Beijing Surgerii Robotics Company Limited

Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd.

Wei Wei

Long Wang

Shuhui Chen

Peng Li

Jian Li

Joseph A Kozlowski

Haiying He

Ping Huang

Jun Zhang

Yu Meng Li

Hao Yang

Jun Xu

Bin Zhao

Bin Hu

Lei Chen

Wensheng Yu

Min Woo Lee

David R Fenn

Ling Tong

Jie Zhu

Huan Liu

Bandarpalle B Shankar

Jiangran Zhao

Zhengchen Dai

Yanfeng Jia

Dong Liu

Razia Rizvi

Yu Yu

Dahai Wang

Tao Ji

Deyou Sha

Jianming Wen

Yuantao Zhao

Yingjian Wang

Chengshuai Yang

Sheng Meng

Bin Zhong

Ning Zhao

Oleg B Selyutin

Bo Liang

Junyue Gao

Jae-Hun Kim

Yuhan Sun

Jinglai Hao

Zhenying Chen

Bangping Gu

Huichao Zhang

Xiong Hu

Stephen Brian Istivan

Zhou Zhou

Craig D Niederst

Juan Wang

Pingping Wang

Zhihua Zhou

Xing Yan

Yongjun Wei

Yong Zang

Timothy Schoenharl

Sui Yin

Decheng Wu

Chaojing Li

Zonghan Wu

Quan Shao

Guangyao Zhang

Philippe Rapold

Xiaojun Zhou

Liujun Zhong

Wenju Wang

Ping Yin

Liyong Qian

Jinxin Liu

Qian Hu

Siqi Wang

Chinming Hui

Jiali Cao

Wukun Mei

Yun Fan

Baoyuan Sun

Bingsheng Zhang

Yanjun Chen

Mei Ge

Chang Shao

Min Rao

Minyu Luo

Yuying Gao

Xing Xia

Qingqian Meng

Lingao Ruan

Wenqing Liu

Zhenwu Yan

Xiaojie Meng

Na Gao

Liming Song

Jiajie Feng

Jintao Lai

Iei Xie

Huqing Liang

Hai Rong Huang

Wuji Lan

Pil Su Kim

Disclosed are a kind of fused ring derivatives, and specifically disclosed are compounds as shown in formula (I) and pharmaceutically acceptable salts thereof.

Fused ring derivatives and use thereof in pharmacy

Systems and methods for predicting that a stock keeping unit (SKU) is likely to be scrapped and performing preventative actions accordingly. The system receives a request to initiate a process related to predicting scrap likelihood associated with a plurality of SKUs, inputs data associated with each SKU into a trained prediction model, outputs, from the trained prediction model, a prediction value for each SKU, measures the trained prediction model by calculating a set of values, and generates a matrix comprising the calculated set of values. Using the matrix, a threshold prediction value is determined, and each SKU prediction value is compared to the threshold prediction value. Based on the comparison, a SKU of the plurality of SKUs is predicted as likely to be scrapped and at least one of a plurality of preventative actions is performed.

Computerized systems and methods for predicting and managing scrap

The present invention relates to a group of glycosyltransferase, and an application thereof. Specifically, provided is using glycosyltransferase GT29-32, GT29-33, GT29-34, GT29-4, GT29-5, GT29-7, GT29-9, GT29-11, GT29-13, GT29-17, GT29-18, GT29-19, GT29-20, GT29-21, GT29-22, GT29-23, GT29-24, GT29-25, GT29-36, GT29-37, GT29-42, GT29-43, GT29-45, GT29-46, PNUGT29-1, PNUGT29-2, PNUGT29-3, PNUGT29-4, PNUGT29-5, PNUGT29-6, PNUGT29-7, PNUGT29-8, PNUGT29-9, PNUGT29-14, and PNUGT29-15, as well as derived polypeptides thereof to catalyze the first glycosyl at position C-20, the first glycosyl at position C-6, and the first glycosyl at position C-3 of a tetracyclic triterpene compound substrate to elongate a carbohydrate chain, thereby obtaining a catalytic reaction of ginsenoside products such as ginsenoside Rg3, ginsenoside Rd, ginseno-side Rb 1, ginsenoside Rb3, saponin DMGG, saponin DMGX, gypenoside LXXV, gypenoside XVII, gypenoside XIII, gypenoside IX, notoginsenoside U, and notoginsenoside R1, notoginsenoside R2, notoginsenoside R3, 3-0-13-(D-xylopyranosyl)-13-(D-glucopyra-nosyl)-PPD, 3-0-13-(D-xylopyranosyl)-13-(D-glucopyranosyl)-CK, 20-O-Glucosylginsenoside Rf, and Ginsenoside F3. Glycosyltrans-ferase in the present invention can further be applied to construction of artificially synthesized ginsenoside, novel ginsenoside, and derivatives thereof.

Group of UDP-glycosyltransferase for catalyzing carbohydrate chain elongation and application thereof

A compound represented by formula (I), isomers or pharmaceutically acceptable salts thereof, and application thereof in the preparation of drugs for treating diseases related to RIP-1 (receptor interacting protein) kinase.

Bicyclic compound as RIP-1 kinase inhibitor and application thereof

A dye composition I may include: a) oxidative dye(s); b) anionic polymer thickener(s); and c) antioxidant(s) including thiol-derived reducer(s). A kit may include (1) the dye composition I and (2) oxidizing composition II, including at least one oxidant. The oxidation base may include a para-phenylenediamine, bis(phenyl)alkylenediamine, para-aminophenol, ortho-aminophenol, heterocyclic base, or mixture thereof, optionally in addition salt form.

Cosmetic composition for the oxidative dyeing of keratin fibres

A dynamic power consumption estimation method includes recording a statistical value of each of n target signals of a to-be-measured target in a unit time, where the target signal is a clock signal obtained after clock gating and the statistical value is a quantity of times toggling, or the target signal is a clock gating signal and the statistical value is a quantity of enable cycles, and calculating the dynamic power consumption of the to-be-measured target in the unit time based on the statistical value of each of the n target signals in the unit time.

Dynamic power consumption estimation method, apparatus, and system

Provided is an accumulative sliding construction method of segmental track-changing for unequal-span structure, which divides the unequal-span structure into at least two sliding sections according to span variation, and a plurality of track segments corresponding to the spans of each sliding section. By providing sliders on the main truss/beam of each sliding section at positions corresponding to the track segments that each main truss/beam need to pass through, the sliding section smoothly passes through the sliding track segments to be in position; in addition, the main truss/beam of each sliding section is provided with temporary lengthening auxiliary structure or divided into an initial-mounted unit and rear-mounted units to allow the main truss/beam of each sliding section to pass through the track segments smoothly and to be in place.

Segmental track-changing and accumulative sliding construction method for unequal-span structure

The invention relates to the technical field of radar detection, in particular to a device for real-time detection of spectrum from airborne hyperspectral imaging LiDAR and method thereof. The device comprises a laser and a reference module; the reference module comprises a first reflecting mirror and a second reflecting mirror with a given transmittance; the first reflecting mirror and the second reflecting mirror are arranged with a focusing mirror and an optical fiber in sequence therebetween. The laser emits a laser light to the first reflecting mirror with a given transmittance, and the beam of the laser light transmitted through the first reflecting mirror after passing the focusing mirror is used as the reference beam after passing the optical fiber. The invention enables detection of the spectral line of each pulse and improves the precision of reflection spectrum of the ground object measured by the system.

Device and method for real-time measuring the spectrum of airborne hyperspectral imaging LiDAR

The invention relates to the technical field of radar detection, in particular to a method for radiation calibration of airborne hyperspectral imaging LiDAR system. The method comprises the following steps: S1. A monochromator in a spectrum calibration system emits optical signals of different spectrum values to scan the radar system, thus to obtain the bandwidth and central wavelength of each channel in the radar system; S2. According to the return signal power P(λ, z) in the hyperspectral LiDAR equation and the optical power P(λ) received by the target surface of the detector in the radar system under experimental conditions, a white diffuse reflection board is taken as the ground object target, and a ranging channel is used to measure the flying height of the radar system, thus to obtain the parameters in the return signal power P(λ, z) and the reflection spectrum β(λ).

Method for radiation calibration of airborne hyperspectral imaging LiDAR system

A dye composition I, comprises: a) at least one oxidative dye(s), b) at least one thickener selected from anionic polymer(s), and c) at least one antioxidant including thiol-derived reducer(s). A kit comprises (1) the dye composition I and (2) oxidizing composition IL, comprising at least one oxidant.

The present invention discloses glycopeptide compounds having activity of resisting drug-resistant bacteria, conforming to glycopeptide compounds represented by general formula (I), The present invention also provides a preparation method for and an application of the glycopeptide compounds. Upon testing, compared with a second-generation glycopeptide drug oritavancin, the glycopeptide antibiotic compounds have higher inhibition activity on drug-resistant bacterial strains, especially MRSA or VRE. Further testing shows that most of the glycopeptide compounds have safety higher than that of oritavancin and can be prepared into drugs for treating or preventing diseases caused by various bacterial infections, such as skin and soft tissue infections, meningitis, sepsis, pneumonia, arthritis, peritonitis, bronchitis, and empyema.

Glycopeptide compounds having activity of resisting drug-resistant bacteria, and preparation method and application thereof

The present invention relates to a group of glycosyltransferase, and an application thereof. Specifically, provided is using glycosyltransferase GT29-32, GT29-33, GT29-34, GT29-4, GT29-5, GT29-7, GT29-9, GT29-11, GT29-13, GT29-17, GT29-18, GT29-19, GT29-20, GT29-21, GT29-22, GT29-23, GT29-24, GT29-25, GT29-36, GT29-37, GT29-42, GT29-43, GT29-45, GT29-46, PNUGT29-1, PNUGT29-2, PNUGT29-3, PNUGT29-4, PNUGT29-5, PNUGT29-6, PNUGT29-7, PNUGT29-8, PNUGT29-9, PNUGT29-14, and PNUGT29-15, as well as derived polypeptides thereof to catalyze the first glycosyl at position C-20, the first glycosyl at position C-6, and the first glycosyl at position C-3 of a tetracyclic triterpene compound substrate to elongate a carbohydrate chain, thereby obtaining a catalytic reaction of ginsenoside products such as ginsenoside Rg3, ginsenoside Rd, ginsenoside Rb1, ginsenoside Rb3, saponin DMGG, saponin DMGX, gypenoside LXXV, gypenoside XVII, gypenoside XIII, gypenoside IX, notoginsenoside U, and notoginsenoside R1, notoginsenoside R2, notoginsenoside R3, 3-O-&#x3b2;-(D-xylopyranosyl)-&#x3b2;-(D-glucopyranosyl)-PPD, 3-O-&#x3b2;-(D-xylopyranosyl)-&#x3b2;-(D-glucopyranosyl)-CK, 20-O-Glucosylginsenoside Rf, and Ginsenoside F3. Glycosyltransferase in the present invention can further be applied to construction of artificially synthesized ginsenoside, novel ginsenoside, and derivatives thereof.

A method for determining the excitation frequency of vibratory stress relief by employing a system for determining the excitation frequency of vibratory stress relief is disclosed, comprising the steps of: connecting the component to the system for determining excitation frequency of vibratory stress relief; selecting a group of preferred excitation frequency of the vibratory stress relief according to the results of numerical simulation; obtaining the reference voltage peak of the sinusoidal signal from the preferred excitation frequency, and transforming the sinusoidal signal into an excitation signal for vibratory stress relief treatment; converting the vibration signal of the component during vibratory stress relief treatment into voltage signal to obtain the actual voltage peak; comparing the actual voltage peak with the reference voltage peak, and selecting the frequency with the maximum difference of voltage peak as the excitation frequency for the vibratory stress relief treatment.

System for determining excitation frequency of vibratory stress relief and method therefor

A computer-implemented systems and methods for intelligent generation of purchase orders is disclosed. The system may be configured to execute instructions for: receiving one or more demand forecast quantities of one or more products, the products corresponding to one or more product identifiers, and the demand forecast quantities comprising a demand forecast quantity for each product for each unit of time; receiving supplier statistics data for one or more suppliers, the suppliers being associated with a portion of the products; receiving current product inventory levels and currently ordered quantities of the products; determining preliminary order quantities for the products; constraining the preliminary order quantities to obtain recommended order quantities based at least on the supplier statistics data, the current product inventory levels, and the currently ordered quantities; and generating purchase orders to the suppliers for the products based on the recommended order quantities.

Systems and methods for optimization of a product inventory by an intelligent adjustment of inbound purchase orders

A debonding leveling device and a debonding method are for leveling during a process for debonding a first object and a second object. The first and second objects are retained by a first fixation plate () and a second fixation plate (), respectively. The device includes: a mounting plate (), disposed at an outer side of one of the first () and second () fixation plates; a connecting rod assembly () fixed around a center position of the mounting plate (), the connecting rod assembly () connected to the one of the first () and second () fixation plates sequentially via a sliding pair () and a spherical pair () connected to the sliding pair (); and at least three elastic assemblies () disposed between the mounting plate and the one of the first and second fixation plates, each of the elastic assemblies coupled to the mounting plate () and the one of the first () and second () fixation plates. The combination of the spherical pair and the sliding pair allows an adaptation of leveling objects to dynamic changes of the reference, and the elastic assemblies performs a leveling for the leveling objects in real-time based on an orientation of the reference. This entails a simple structure with a reasonable layout, which is easy to use in practice and is particularly helping in dynamic leveling applications without requiring an active control.

De-bonding leveling device and de-bonding method

Growing community of inventors

Shanghai, China

Wei Wei