Roche Diagnostics Operations, Inc.

Centaurus Biopharma Co., Ltd.

Cspc Zhongqi Pharmaceutical Technology (shijiazhuang) Co., Ltd.

Beta Pharma Canada Inc.

Cspc Zhongqi Pharmaceutical Technology Co., Ltd.

Wei W Yuan

Gerald F Sigler

Raymond Hui

Armen B Shanafelt

Richard Terry Root

Christopher C Lawrence

This application relates to a compound of Formula ! (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an antagonist of receptor CRTH2, as well as a process for its preparation and intermediates therefor.

Heterocyclic compounds as CRTH2 receptor antagonists

The invention relates to compounds of Formula (I) (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating biological processes including antagonism of Prostaglandin EP4 receptor as a therapeutic treatment.

Heterocyclic amide derivatives as EP4 receptor antagonists

Analogs of saquinavir functionalized at the quinoline portion of the molecule are described. These include pyridyl analogs (replacing the quinoline ring) with a functional handle out of the ring allowing for elaboration with linkers terminated by a functional group such as an activated ester which are useful for attaching the molecule to other entities such as proteins, polysaccharides, and the like. Analogs of saquinavir derivatized out of the quinoline ring are also described.

Saquinavir derivatives useful in immunoassay

A method of treating particles to be used in immunoassays reduces interference in particle agglutination assays. For particles having covalently bound antibodies and residual NHS-ester or sNHS-ester groups on the surface, the reactive esters are treated with an aqueous mixture containing an amine compound of formula (I):HN&#x2014;R&#x2014;X&#x2003;&#x2003;(I).The moiety &#x2014;X is &#x2014;NH, &#x2014;OH, or &#x2014;COCHCH; and R is an alkyl group or an alkyl ether group. When &#x2014;X is &#x2014;NHor &#x2014;COCHCH, R contains from 1 to 20 carbon atoms; and when &#x2014;X is &#x2014;OH, R contains from 4 to 20 carbon atoms.

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Fishers, IN, United States of America

Wei W Yuan