National Chung Cheng University

Wei-Ting Hsu

Lai-Kwan Chau

Wen-Hsin Hsieh

Guo-Hua Feng

Cheng-Lung Cho

Po-Liang Chen

Shu-Fang Cheng

The method for processing a sensor chip in accordance with the present invention has: 1) providing an acoustic wave operation system and a biochemical sensor chip, wherein the acoustic wave operation system has a piezoelectric transducer generating at least one cycle of longitudinal acoustic waves by a driving voltage and wherein a probe is immobilized on a surface of the biochemical sensor chip; 2) arranging the piezoelectric transducer at a distance from the biochemical sensor chip and filling therebetween with a medium for transmitting longitudinal acoustic waves; and 3) applying longitudinal acoustic waves to the biochemical sensor chip to remove an adsorbate bound to the probe.

Method for processing a sensor chip

A sensing system comprises a light source, an optical fiber, a plurality of noble metal nano-particles, a micro-fluidic module and a photo detector. The optical fiber couples an incident light. The plurality of noble metal nano-particles are disposed on a surface of the optical fiber to form a noble metal nano-particle submonolayer, the noble metal nano-particles are substantially separated from each adjacent noble metal nano-particles such that the conductivity of the noble metal nano-particle submonolayer is smaller than that of a metal film. The micro-fluidic module accommodates the optical fiber and a sample, and the sample is driven to contact with the noble metal nano-particles. The photo detector detects an emergent light from the optical fiber. When the incident light interacts with the noble metal nano-particles, a signal derived from localized surface plasmon resonance in form of attenuated light or elastic scattered light is outputted through the photo detector.

Localized surface plasmon resonance sensing system, appartatus, method thereof

A bio-sensing system comprises a light source, a bio-sensing apparatus, a detecting platform, and a processing unit. A bio-sensing apparatus further comprising a substrate, a sample with at least one analyte, at least one grating bound on the substrate for diffracting a light beam in a reflection mode and outputting at least one output light beam, a plurality of nanoparticles being bound on one side of the grating, a molecular recognition unit bound on said nanoparticle surface, and a cover plate covering the nanoparticle-modified side of the substrate. The detecting platform receives a signal while the at least one output light beam passing through the bio-sensing apparatus. The processing unit couples with the detecting platform for receiving and analyzing the signal. Wherein when the analyte passes through the microfludic channel to contact with said nanoparticles, the at least one output light beam changes in accordance with the refractive index of the sample or in accordance with the interaction of the analyte with said molecular recognition unit bound on said nanoparticle surface.

Biosensing apparatus and system

A surface plasmon resonance sensing system and method thereof are disclosed. The system comprises an incident light source, a sensing element, a noble metal nanoparticle layer, a sample loading unit, and a light detector. The noble metal nanoparticle layer is composed of one of noble metal nanoballs, noble metal nanorods and noble metal nanoshells. The noble metal nanoparticle layer is disposed on the sensing element. The sample loading unit is used to allow a sample to be contacted with the noble metal nanoparticle layer. The light detector is used to detect an emergent light of the sensing element.

Growing community of inventors

Taipei County, Taiwan

Wei-Ting Hsu