Atomic Energy Council-Institute of Nuclear Energy Research

Wei-Ti Kuo

Wuu-Jyh Lin

Yu Lung Chang

Cheng-Fang Hsu

Mei-Hui Wang

Chih-Yuan Lin

Jen-Tsung Wang

Hung-Wen Yu

A method for preparing a precursor used to label hepatocyte receptors is revealed. The precursor contains a bifunctional structure including trisaccharide and DTPA ligand. During synthesis processes of the precursor, silica gel columns and Reverse phase-18 (RP-18) columns are used for purification. Thus both the purification times and cost of each purification are reduced. Moreover, use diethyl ether to facilitate precipitation of products and remove a part of coupling reagent. Removing the coupling reagent helps purification of products. Furthermore, N,N-bis(carboxymethyl)-L-lysine hydrate and benzyl chloroformate are coupled to form a trisaccharide skeleton so as to ensure the yield rate of trisaccharide structure.

Method for preparing precursor used for labeling hepatocyte receptor and containing trisaccharide and DTPA ligand

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Kaohsiung, Taiwan

Wei-Ti Kuo