Nr Electric Co., Ltd

Nr Engineering Co., Ltd

Other

Tencent Technology (shenzhen) Company Limited

Nanjing University

Honeywell International Inc.

Hand Held Products, Inc.

Affiliated Hospital of Nantong University

China Railway Engineering Equipment Group Co., Ltd.

Wei Shi

Dongming Cao

Taixun Fang

Bing Yang

Lin Liu

Yi Chen

Chang He

Song Jian Wang

Shan Chen

Lingfeng Xu

Qiang Tu

Zhenquan Wu

Ming Huang

Zurong Wu

Yumiao Zhang

Xingxing Dai

Yehui Huang

Feng Xiong

Hongxia Yu

Yifan Yang

Wenhui Lai

Min Zhou

Ling Yang

Yu Wang

Wei Xiao

Yeyuan Xie

Wei Zhai

Wenjie Wang

Jianli Li

Wei Lv

Shanchun Wang

Tao Wang

Xunqiang Wang

Wei Lu

Hao Yang

Wei Li

Lin Feng

Jianbin Li

Weiming Chen

Ying Zhu

Moubang Li

Danni Lin

Pengfei Zhong

Richeng Xiao

Chuanqing Li

Qianqian Lin

Yanxue Chong

Zengkang Liao

Cong Tang

Junchao Wang

Jianwei Kuang

Bin Liu

Kop Liu

Lianhui Jia

Qinchang Chen

Yadong Miu

Lele Li

Zhihua Dai

Minxue Xu

Haoyue Tan

Zhonghua Tan

Xiaoxiang Wang

Zhifeng Gu

ZhaoXiu Liu

ZhiQiang Liu

Jing Guo

Jingo Zhao

Chuanfang Wang

Yeqi Liu

Mingbing Xiao

Tianren Yang

Yangyi Yan

Qian Zhou

Dan Lv

Qingzeng Yu

Lixun Zhang

Juhui Yang

Xidong Zhang

Dujuan Wang

Xingjian Zhuo

Wei Wang

The present invention provides a detection device of dot immunoblotting detection, including a negative pressure suction device, a hole plate, a hose for connecting the hole plate with the negative pressure suction device, and a nitrocellulose membrane in tight fit with the upper end surface of the hole plate. The present invention further provides a detection method of dot immunoblotting detection, including preparation, sample injection, blocking, incubation of a primary antibody, incubation of a secondary antibody, development and analysis. The detection method performs negative pressure suction through the negative pressure suction device, which is favorable for concentrating samples during sample injection and avoiding the influence, caused by cross contamination after diffusion of the samples, on an experimental result, and the experimental result is more accurate.

Detection device and detection method of dot immunoblotting detection

The present invention provides a model for high-throughput screening of endocrine disruptors and a method for screening the same. In the present invention, primary structural alerts, secondary structural alerts and tertiary structural alerts of compounds are extracted according to a nuclear receptor, and then the primary structural alerts, the secondary structural alerts and the tertiary structural alerts form a nuclear receptor high-throughput screening model; hierarchical structural alert matching is carried out on target compounds through the nuclear receptor high-throughput screening model, and ligand-receptor binding mode analysis and semi-quantitative prediction of binding activity and disrupting activity are performed. According to the present invention, the defect in prior art that potential nuclear receptor-mediated endocrine disruptors cannot be effectively screened in high throughput is overcome, high-throughput screening of potential nuclear receptor-mediated endocrine disruptors can be performed, and receptor competitive activity and A-Anta activity of the nuclear receptor-mediated endocrine disruptors can be determined.

Model for high-throughput screening of endocrine disruptor and method for screening same

The present invention relates to a small spatial sound source orientation detecting device, including a circuit board; three or more MEMS acoustic-electric transducers fixedly arranged on the circuit board and centrosymmetric distribution. The distance between adjacent MEMS acoustic-electric transducers is not more than one-half of the shortest wavelength of the sound source signal; and a micro-control unit, each MEMS acoustic-electric transducer is electrically connected to the micro-control unit respectively. The micro-control unit is to obtain the orientation information of the spatial sound source based on the acoustic signals collected by three or more MEMS acoustic-electric transducers. The present invention also provides a spatial sound source orientation detection method. The small spatial sound source orientation detecting device of the present invention has an ultra-small space size, and can accurately detect the orientation information of the sound source.

Small spatial sound source orientation detecting device and method thereof

A resource sharing method is performed at a mobile terminal, the method including the following steps: obtaining configured user identifier; obtaining multimedia data; obtaining a resource sharing request, and associating the user identifier with the multimedia data according to the resource sharing request; generating a resource sharing instruction according to an association relationship between the user identifier and the multimedia data; and executing the resource sharing instruction.

Resource sharing method and terminal

A closing control method for a high-voltage DC circuit breaker. The method comprises: closing breaking units of the transfer branch () group by group, then closing the main branch (), and finally open the transfer branch. During the process of closing the breaking units of the transfer branch group by group, determine whether there is a fault in the power transmission system after closing current breaking unit group. if there is no fault, proceed to close the next breaking unit group until all breaking unit groups are closed before proceeding to the next step; if there is a fault, all the breaking units that have been closed are opened and the closing operation is ended. The method can pre-charge the power transmission system during the closing process of the high-voltage DC circuit breaker, and lower the overvoltage and system oscillation caused by the closing operation.

Closing control method for high-voltage direct-current circuit breaker

The present application provides a quinoline derivative against non-small cell lung cancer. 1-[[[4-(4-fluoro-2-methyl)-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclopropylamine or a pharmaceutically acceptable salt thereof provided by the present application can be used for the treatment of non-small cell lung cancer, and relative to placebo, can significantly improve non-small cell lung cancer patients without progression of survival. 1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclo propylamine or a pharmaceutically acceptable salt thereof provided by the present application can be used for the treatment of lung adenocarcinoma, and relative to placebo, can significantly improve lung adenocarcinoma patients without progression of survival.

Quinoline derivatives for non-small cell lung cancer

A resource sharing method is performed at a mobile terminal, the method including: configuring a to-be-shared resource by using a processor, to obtain data needed for obtaining a resource; obtaining a user identifier of a currently logged-in social networking application; obtaining a resource sharing message image template, a user-defined visible element, and configuration information of the visible element that are associated with the user identifier; drawing a resource sharing message image according to the resource sharing message image template, the visible element, and the configuration information, and displaying the resource sharing message image on a social network propagation page of the social networking application; and transferring, by using a social network, a resource sharing message corresponding to the resource sharing message image, the resource sharing message including the data needed for obtaining a resource.

A resource sharing method is performed at a mobile terminal, the method including: receiving a resource sharing message configuration file that is delivered in a pre-configured delivery time period; obtaining a theme activity time period according to the resource sharing message configuration file; displaying a resource sharing message configuration portal in the theme activity time period; detecting an operation on the resource sharing message configuration portal, and entering a resource sharing message configuration page; obtaining, according to a configuration performed on the resource sharing message configuration page, a resource sharing message template matching the theme activity time period and resource information matching the resource sharing message template; generating a resource sharing message according to the obtained resource sharing message template and resource information, the resource sharing message including data for obtaining a resource; and sharing the resource sharing message.

Systems and methods are disclosed for a soft power start solution based on a two pin connector for a device such as a mobile terminal. When a charging pad of the device is first docked to a charging cradle, the charging pad of the device is connected to a plunger in a ground pin, but power is not applied at that moment. In a separate step, the plunger is shorted to a spring flat that allows power to be applied to the charging pad. Similar steps occur during de-docketing. With this method, contact interface burn caused by electrical arcing when docking or de-docking a mobile terminal from a charging cradle may be minimized.

POGO connector based soft power start solution

Implementations herein relates to effect-directed identification of targeted and non-targeted androgen disruptors. The implementations include primary separation, androgenic activity testing, high throughput separation and preparation of toxicants, active component scanning based on high performance liquid chromatography-time of flight mass spectrometry, targeted screening of suspicious androgenic substances, non-target identification of androgenic compounds combining mass spectrum, chromatography and toxicity characteristics and toxicity confirmation. The implementations perform separation using SPE and preparative separation in series to obtain high throughput separation fractions, utilize DMSO as a protective agent to optimize concentration of second fractions, utilize target databases to achieve target identification of key toxicants. In addition, assess mass spectrum characteristic identification based on TOF-MS library spectrum, assess chromatography characteristic identification methods based on relationship between retention times and characteristics of compounds, assess toxicity characteristic identification methods based on molecular dynamics simulation techniques, and further assess non-targeted identification and determination of key androgenic substances in the fractions.

Effect-directed identification of targeted and non-targeted androgen disruptors

A bridge-type circuit comprises a H-bridge switch module and a buffering and reclosing module. The H-bridge switch module comprises four power semiconductor switch devices. Every two of the four power semiconductor switch devices are connected in series in the same direction to form a bridge arm, and the two bridge arms are further connected in parallel. Middle points of the two bridge arms respectively serve as an input terminal and an output terminal. The buffering and reclosing module is connected in parallel with the two bridge arms of the full bridge module. Also provided are a direct current breaking device formed by connecting the above bridge-type circuits in cascade and a control method thereof. The direct current breaking device is provided with the buffering and reclosing module, such that line voltage fluctuation generated during a reclosing operation is small.

Bridge-type circuit, and direct current breaking device and control method thereof

A direct current switch-off device comprises an on-state current branch circuit and a current commutating and breaking unit which are connected in parallel. The on-state current branch circuit has a mechanical switch (S) and a current transfer module which are connected in series. The current commutating and breaking unit comprises a bridge-type branch circuit and a current-breaking branch circuit. The current-breaking branch circuit and two bridge arms of the bridge-type branch circuit are connected in parallel. The current-breaking branch circuit comprises a nonlinear resistor (RI) and a valve group consisting of fully-controlled devices connected in series. The nonlinear resistor (RI) and the valve group are connected in parallel. Two ends of each fully-controlled device in the valve group are connected in parallel with a buffering and reclosing circuit.

Direct current switch-off device and control method thereof

The present application provides a quinoline derivative against non-small cell lung cancer. 1-[[[4-(4-fluoro-2-methyl)-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclopropylamine or a pharmaceutically acceptable salt thereof provided by the present application can be used for the treatment of non-small cell lung cancer, and relative to placebo, can significantly improve non-small cell lung cancer patients without progression of survival. 1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclopropylamine or a pharmaceutically acceptable salt thereof provided by the present application can be used for the treatment of lung adenocarcinoma, and relative to placebo, can significantly improve lung adenocarcinoma patients without progression of survival.

Quinoline derivative against non-small cell lung cancer

The present patent relates to a method for qualitative identification and quantitative prediction of thyroid hormone disrupting chemicals base on the interaction between thyroid hormone receptor and co-regulators (coactivator and corepressor). The method identifies chemicals as passive antagonists, active antagonists and agonists by means of co-regulator involved molecular dynamics simulations, and predicts the relative disrupting potencies by use of binding free energy, therefore, may be used for screening of thyroid hormone disruptors among environmental pollutants. Upon more comprehensive consideration of the functioning mechanism of thyroid hormone receptor, the present invention is able to sufficiently identify thyroid hormone disruptors as agonists and antagonists, and gives more accurate prediction of the disrupting potency. Further, since nuclear receptors, just as thyroid hormone receptor, are strongly associated with co-regulators, the method may be expanded to the screening of nuclear receptor mediated endocrine disruptors.

Screening methods for thyroid hormone disruptors based on co-regulator involved simulations

The present invention provides a locking mechanism in a mobile terminal and method of manufacturing the same. The locking mechanism comprises a lock button, a slide latch, and spring member. The slide latch may slide between a first position and a second position and comprises a hole and snaps, the hole is on the top of the slide latch and extends through the slide latch, the snaps are at the front side of the slide latch. The lock button is in the hole and comprises a press part and a support part, the support part being connected to the press part and extending downward from the press part through the hole to be in contact with the contact part on the spring member; the spring member is fixed with the slide latch and comprises an spring reaction part, a contact part and a protrusion part, the contact part being in contact with the support part of the lock button and a force from the support part causing a spring deformation in the spring reaction part.

Battery cover locking mechanism of a mobile terminal and method of manufacturing the same

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Jiangsu, China

Wei Shi