National Cheng-Kung University

Wei-Pang Chung

Wei-lun Huang

Hsisheng Teng

Wu-chou Su

Hai-wen Chen

Te-fu Yeh

I-Ting Chiang

Liang-Che Chen

A molecular probe includes a detector molecule specific to a target molecule, and at least one label linked covalently or non-covalently to the detector molecule. The label includes a catalyst for generating electrons and/or mediators from a solution. The catalyst includes a nanomaterial, an enzyme, a metal, and/or a metal complex. The mediators can accumulate in the solution for a period of time. The detector molecule and the target molecule interact with each other by a protein based or nucleotide sequence based interaction. The mediators participate in a chemical reaction that generates a signal that may be a change in optical, electromagnetic, thermodynamic or mechanical properties. Generation efficiency of the mediators is enhanced by providing an energy to the solution. The molecular probe may be used with a molecular detection assay performed on a surface. A method for assaying the target molecule using the molecular probe is also provided.

Molecular probe for signal amplification and kit and assay using the same

Growing community of inventors

Tainan, Taiwan

Wei-Pang Chung