Acea Biosciences, Inc.

Agilent Technologies, Inc.

Wei Ouyang

Xiaobo Wang

Xiao Xu

Yama A Abassi

Nan Li

Tianxing Wang

Xiaoyu Zhang

Biao Xi

Devices, systems and methods for monitoring excitable cells, such as cardiomyocytes, on microelectrode arrays that couple the electro-stimulation of excitable cells to induce or regulate cardiomyocyte beating and the simultaneous measurement of impedance and extracellular recording to assess changes in cardiomyocyte beating, viability, morphology or electrophysical properties in response to a plurality of treatments.

System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties

Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.

System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function

System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties

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San Diego, CA, United States of America

Wei Ouyang