Jiangsu Nhwaluokang Pharmceutical Research and Development Co., Ltd.

Other

Jiangsu Nhwaluokang Pharmaceutical Research and Development Co., Ltd.

Li, Qingeng

Wei Mao

Lingguo Zeng

Tao Wang

Qingeng Li

Tong Wu

Gang Chen

Yuanzhong Wang

Dahai Chen

The present invention discloses a class of carboxylic acid derivatives and use thereof in preparation of prodrugs. The carboxylic acid derivatives have the general formula (I), wherein Ris H or alkyl; X is H or F; Y is F or fluoroalkyl; n is 0, 1, 2, 3, 4, 5, or 6; W is Wor W; Wis NRR, NRR.A, Rand Rare each independently H, alkyl, cycloalkyl, or a protecting group for amino; m is 0, 1, 2, or 3; A is an acid; Wis COOR, OPO(OR), or PO(OR); Ris H, or a protecting group for carboxyl or hydroxyl in phosphoric acid. 

Carboxylic acid derivatives and use thereof in the preparation of prodrugs

The present invention discloses a class of water soluble taxane derivatives, a method for treating tumor using the same, use thereof as anti-tumor drugs and use thereof in the preparation of anti-tumor drugs. The water soluble taxane derivatives have the general formula (I-1), (I-2) or (I-3): wherein, Ris H or methyl; Ris H, methyl or acetyl; Ris phenyl or OC(CH); X is H, Calkyl or F; Y is F or Calkyl substituted with one or more F; n is 1, 2, 3, 4, 5 or 6; W is NRR.A or Rand Rare each independently H, Calkyl optionally substituted with phenyl, or Ccycloalkyl; m is 0, 1, 2 or 3; and A is a pharmaceutically acceptable acid. 

Water-soluble taxane derivatives and uses thereof

The present invention discloses a class of water-soluble propofol derivatives, preparation method thereof, anesthetization method using the same, use thereof as prodrugs and use thereof in the preparation of intravenous anesthetics. The water-soluble propofol derivatives have the general formula (I); wherein X is H or F, Y is F or alkyl substituted by one or more F, n is 1, 2, 3, 4, 5 or 6, W is Wor W; Wis NRR.A or Rand Rare each independently H, alkyl optionally substituted with phenyl, or cycloalkyl, m is 0, 1, 2 or 3, A is a pharmaceutically acceptable acid, Wis COOMor OPO(M)or PO(M); M is a metal ion, an ammonium ion or a basic amino acid cation which can form a salt with an acid radical; t is the charge number of M. 

Water-soluble propofol derivatives and uses thereof

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Chongqing, China

Wei Mao