Agency for Science, Technology and Research

Institute of Materials Research and Engineering

Nanyang Technological University

Osram Opto Semi-conductors Gmbh Co. Ohg

Agency for Science, Technology and Research (a*star)

Osram Opto Semiconductor Gmbh Co. Ohg

Wei Ling Wang

Athisayamani Jeyaraj Duraiswamy

Soo Yei Ho

Jenefer Alam

Liang Hong

Zetao Xia

Soo Jin Chua

Ewald Karl Michael Guenther

Zhiping Wang

Zhaolin Liu

Teng Sheng Peh

Anders Poulsen

Thomas Hugo Keller

Changming Li

Zhao Lin Liu

Gang Wang

Wei Hung

Huanming Xia

Congbao Kang

There are provided new heterobifunctional agents designed to mediated formation of protein-protein dimers and promote ubiquitination of a protein of the dimer. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by protein over-expression or malfunction.

Therapeutic compounds and methods of use thereof

The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein.

WNT pathway modulators

The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein each of R, R, R, R, R, W, X, Y, Z, and n is as defined herein.

The present invention relates to dihydropyrazolo[1,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making them, and pharmaceutical compositions comprising them. Methods of treatment of conditions mediated by WNT pathway signalling including cancer, fibrosis, stem cell and diabetic retinopathy, rheumatoid arthritis, psoriasis and myocardial infarction, comprising the compounds of formula I are also provided. 

Wnt pathway modulators

The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein Rrepresents optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from Calkoxy); optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C-6alkyl, Calkoxy, Chaloalkyl, Chaloalkoxy and halo); or -alkylaryl; Rrepresents H; or alkyl; Rrepresents H; or alkyl; U, V and W represent &#x2014;(CH)&#x2014;; or U and V together represent &#x2014;CH&#x2550;CH&#x2014; and W represents C&#x2550;O; Y represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from Calkyl, Calkoxy, Chaloalkyl, Chaloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from Calkyl, Calkoxy, &#x2014;C(O)OCalkyl, &#x2014;C(O)Calkyl and &#x2014;C(O)NHCalkyl); and Z represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from Calkyl, Calkoxy, Chaloalkyl, Chaloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from Calkyl, Calkoxy, &#x2014;C(O)OCalkyl, &#x2014;C(O)Calkyl and &#x2014;C(O)NHCalkyl). 

Maleimide derivatives as modulators of wnt pathway

The present invention relates to a perovskite-type strontium titanate, wherein the strontium titanate is Y- and Ni-doped and has the general formula (Sr,Y)(Ti,Ni)O. A method of preparing the perovskite-type strontium titanate and its use are also provided.

Perovskite-type strontium titanate

According to various embodiments, a microfluidic agitator device may be provided. The microfluidic agitator device may include: an air inlet; an air outlet; an elastic diaphragm provided between the air inlet and the air outlet and configured to oscillate if an airflow from the air inlet to the air outlet is provided; and a chamber coupled to the elastic diaphragm.

Microfluidic agitator devices and methods for agitation of a fluid

A microfluidic droplet generator device, a kit of parts for assembling a microfluidic droplet generator device, and a method of generating microfluidic droplets. The generator device comprises a substrate; a microfluidic channel formed in the substrate; a fluid outlet in fluid communication with the microfluidic channel; and a mechanical element configured such that vibration of the mechanical element causes droplet dispensing from the fluid outlet.

Microfluidic droplet generator

The present invention relates to a method for forming a catalyst comprising catalytic nanoparticles and a catalyst support, wherein the catalytic nanoparticles are embedded in the catalyst support, comprising forming the catalytic nanoparticles on carbon particle, dispersing the carbon particle in a solution comprising precursors of the catalyst support to form a suspension, heating the suspension to form a gel, subjecting the gel to incineration to form a powder, and sintering the powder to form the catalyst.

Method for forming a catalyst comprising catalytic nanoparticles and a catalyst support

The present invention refers to a droplet-based miniaturized device with on-demand droplet-trapping, -fusion, and -releasing. The device makes use of different electrical fields for directing droplets into microwells and releasing them from the same. In another aspect, the present invention refers to a system comprising such a microfluidic device and a method of operating it.

Droplet based miniaturized device with on-demand droplet-trapping, -fusion, and -releasing

An encapsulation for an electrical device is disclosed. The encapsulation comprises plastic substrates which are laminated onto the surface of the electrical device. The use of laminated plastics is particularly useful for flexible electrical devices such as organic LEDs.

Growing community of inventors

Singapore, Singapore

Wei Ling Wang