Foundry Therapeutics, Inc.

Nanyang Technological University

Wei Li Lee

Honglei Wang

Koon Kiat Teu

Daniel Boon Lim Seet

Hanson S Gifford, Iii

Karun D Naga

Jingnan Luo

Jackie Joe Hancock

Say Chye Joachim Loo

Patrick H Ruane

Stephen W Boyd

John H Morriss

Martin L Mayse

Michael Feldstein

Yit Lung Khung

Peixin Wee

Nassireddin Mokarram-Dorri

The present technology relates to depot assemblies for the controlled, sustained release of a therapeutic agent. The assembly can include a depot having a therapeutic region comprising a therapeutic agent, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.

Implantable polymer depots for the controlled release of therapeutic agents

The devices, systems, and methods disclosed herein may be directed to a delivery system including a therapeutic member configured for endoluminal placement via the delivery system into the esophagus of the patient, wherein the therapeutic member comprises a treatment portion comprising a film for controlled release of a chemotherapeutic agent. The film may comprise a control region, a therapeutic region, and a substantially impermeable base region. The film is configured to release the chemotherapeutic agent in a direction away from the substantially impermeable base region. The delivery system is configured to enable a treatment provider to position the treatment portion of the therapeutic member proximate to a treatment site associated with the esophagus of the patient, and the therapeutic member is configured to administer a therapeutically effective dose to the treatment site for a sustained period following endoluminal placement of the therapeutic member.

Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents

The present technology relates to polymer implants. In some embodiments, the polymer implant may have a volume having minimum cross-sectional dimension of 400 μm. The polymer implant may be configured to be implanted within a mammalian body for at least 3 days without undergoing core acidification.

Polymer implants

The present invention relates to a method for encapsulating particles of a water-insoluble material within a capsule of a water-insoluble polymer, comprising (a) dispersing particles of the water-insoluble material or a solution containing the water-insoluble material in a first aqueous phase containing a first surfactant to obtain a first dispersion; (b) collecting the particles of the water-insoluble material coated with the first surfactant; (c) washing the collected particles; (d) adding the washed surfactant-coated water-insoluble material particles to a polymer solution containing the water-insoluble polymer of the capsule to obtain a polymer mixture; and (e) dispersing the polymer mixture in a second aqueous phase containing a second surfactant to obtain a second dispersion comprising the particles of the water-insoluble material encapsulated within the capsule of the water-insoluble polymer.

Method for encapsulating particles

The invention relates to capsules encapsulating particles loaded with one or more drugs, and in particular, to such capsules that are able to float. The capsules may be used for drug delivery in the gastrointestinal tract. Methods for forming the capsules are also disclosed, and in particular, double emulsion methods are used in forming the capsules.

Floating capsules encapsulating particles loaded with one or more drugs

Growing community of inventors

Singapore, Singapore

Wei Li Lee