Westinghouse Air Brake Company

University of Pittsburgh

Westinghouse Air Brake Technologies Corporation

Union Switch & Signal, Inc.

Wei Li

Gary M Sich

Daniel G Scott

John B Carroll

Robert D Dimsa

Gregory L Johnston

Vincent F Troiani

Michael J Veltri

Dimiter Stanchev Dimitrov

John W Mellors

Paul J Boget

Dontcho V Jelev

Chuan Chen

Zehua Sun

This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, and/or antibody domain) to a SARS-CoV-2 antigen. For example, binders (e.g., antibodies, antigen binding fragments, and antibody domains) that bind to a SARS-CoV-2 polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having COVID-19 (or a viral infection caused by SARS-CoV-2) are provided.

Molecules that bind to SARS-CoV-2

A ramp actuating mechanism for a rail vehicle having a movable ramp and a movable draft arm and coupler arrangement, wherein a spring assisted apparatus can be associated with the movable draft arm and coupler arrangement to counterbalance the load of the movable draft arm and coupler arrangement.

Spring assisted apparatus for ramp actuating mechanism and movable draft arm arrangement

A dual valve fitting enables pressure within a housing to be quickly measured. The fitting includes first and second valve bodies. The first body defines a passage between its threaded and protuberant ends. In the passage, a first valve atop a valve stem features a poppet head that is seatable against an outer valve seat. A first biasing mechanism compels the poppet head against the outer valve seat so that the first valve is normally closed. The second body defines a bore between its upper and lower threaded ends which communicates with the passage. The upper threaded end connects with the threaded end of the first body whereas the lower threaded end is designed to screw into a threaded bore of the housing. In the bore, a second valve features a retainer whose top defines a recess that retains a seal element that is seatable against an inner valve seat. A second biasing mechanism acts upon the retainer so that the seal element therein seats against the inner valve seat thereby rendering the second valve normally closed. A stem extension is disposed between a bottom of the valve stem and the top of the seal element. When a female coupler of a quick connect device is mated to the protuberant end, the female coupler causes translation of the valve stem, the stem extension and the retainer thereby opening both the first and second valves. This allows air to flow from the housing through the fitting and into the female coupler.

Dual valve fitting for enabling quick measurement of pressure

A dual valve fitting enables quick measurement of pressure contained within a housing. The fitting includes a valve body, a valve retainer, first and second sealing rings and a biasing mechanism. The valve body defines a flow passage within which is situated the valve retainer. The valve body is designed at its protuberant end to mate with a female coupler of a quick connect device and at its threaded end to screw into a threaded bore of the housing. The valve retainer defines around itself first and second annular recesses each of which spaced apart from the other to match the spacing of outer and inner annular valve seats formed in the flow passage. Forming a first valve, the first sealing ring retains in the first annular recess so as to be seatable against the outer valve seat. Forming a second valve, the second sealing ring retains in the second annular recess so as to be seatable against the inner valve seat. The valve retainer is biased within the flow passage so that the first and second sealing rings seat against the outer and inner valve seats, respectively, thereby rendering the first and second valves normally closed. Mating the female coupler to the protuberant end of the fitting causes the valve retainer to move inwardly against the biasing mechanism so as to open the first valve first then the second valve thereby allowing flow from the housing through the flow passage and into the female coupler.

A dual valve fitting enables pressure within a housing to be quickly measured. The fitting defines a passage between its threaded and protuberant ends. The threaded end screws into the housing. In an upper section of the passage, a first valve atop a valve stem features a poppet head that is seatable against an outer valve seat. A first biasing mechanism compels the head against the outer seat to keep the first valve normally closed. In a lower section of the passage, a second valve features a seat piece and a valve retainer. On its periphery, the seat piece carries an o-ring which sealingly secures the piece within the passage. The piece defines an inner bore between its ends and has an inner valve seat on its bottom. The top of the retainer is extendable through this inner bore to a point a dead space apart from a bottom of the stem. Around its bottom, the retainer carries an annular check valve. A second biasing mechanism acts upon the retainer so that the check valve seats against the inner seat thereby rendering the second valve normally closed. When a female coupler of a quick connect device is mated to the protuberant end, it causes the stem to move inwardly so that its head unseats from the outer seat and its bottom moves through the dead space and pushes the retainer to unseat the check valve. This enables air to flow the housing through the fitting into the female coupler.

A dual valve fitting enables pressure within a housing to be quickly measured. The fitting includes a single valve body that defines a passage between its threaded and protuberant ends. The threaded end is designed to screw into a threaded bore of the housing. In an upper section of the passage, a first valve features a poppet head atop a valve stem. The poppet head is seatable against an outer annular valve seat formed in the protuberant end of the passage. A first biasing mechanism compels the poppet head against the outer valve seat so that the first valve is normally closed. In a lower section of the passage, a second valve features a retainer whose top defines a recess that retains a check seal element used for seating against an inner annular valve seat formed in the passage. A second biasing mechanism acts upon the retainer so that the check seal element seats against the inner valve seat thereby rendering the second valve normally closed. The bottom of the valve stem is separated a dead space apart from the top of the check element. When a female coupler of a quick connect device is mated to the protuberant end, the female coupler causes the valve stem to move inwardly so that its poppet head unseats from the outer valve seat and its bottom end moves through the dead space to unseat the check element. This enables air to flow from the housing through the fitting into the female coupler.

The invention provides an on-board electrical power generator for application on railway cars as a power supply for Electronically Controlled Pneumatic (ECP) brake equipment and other on-board electronic devices, such as an end of train unit. The generator unit can by operated by vehicle vibration when the train is moving, or by fluid pressure from the brake line when the train is stopped. The generator unit has a magnetic piston surrounded by a coil and is engaged on either end by diaphragm-spring combinations. This arrangement creates a mass-spring system in which the magnetic piston vibrates under external excitation. The oscillation of the magnetic piston as a result of vehicle movement allows interaction between the magnetic piston and a coil and thus generates electrical voltage across the coil as a result of vibration. The diaphragms of the diaphragm-spring combinations create two sealed chambers on the first and second ends of the generator which allows the piston to be actuated by fluid pressure. Fluid pressure from a control valve alternately flows between the first chamber and the second chamber causing the piston to oscillate and thus create an electrical voltage across such coil and thereby generating electrical power.

On-board electrical power generator operated by vibration or compressed

A brake pipe pneumatic valve attachable to an end of a railway vehicle having a first flexible air hose for transmitting brake pipe pressure, and the end-of-train device with a second flexible air hose. The valve includes a housing having first, second, and third ports. The first port is releasably connectable to the first flexible air hose; the second port is releasably connectable with the second flexible air hose; and the third port is releasably matable with a coupling connected to a helper locomotive brake pipe. The valve includes a piston that divides the housing into first and second chambers. The first chamber communicates with the first and third ports; the second chamber communicates with the second port. Also, the piston has a channel therethrough connecting the first and second chambers. The valve further includes first biasing means, disposed between the housing and the piston, for selectably urging the piston towards sealing the first port. Second biasing means, disposed between the housing and the piston, for selectably urging the piston away from sealing the first port and acting to oppose the first biasing means is used, and is an operating pin. The valve includes coupling means attached to the housing releasably matable with a glad-hand coupling. The coupling means includes a mating surface with a protruding locking tongue, an aperture in communication with the third port, and a locking lip that is arranged with respect to the mating surface to form a locking channel.

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Pittsburgh, PA, United States of America

Wei Li