The Feinstein Institutes for Medical Research

The Feinstein Institute for Medical Research

Wei Li

Kevin J Tracey

Haichao Wang

Ping Wang

Andrew E Sama

Jianhua Li

A method of treating a disease or reducing the development of a symptom of a disease in a subject by administering to the subject an amount of tetranectin protein or a tetranectin peptide agonist effective to treat or reduce development of the disease or disease symptom.

Use of tetranectin and peptide agonists to treat inflammatory diseases

Methods of treating sepsis or endotoxemia in a subject comprising administering to the subject an amount of an antagonist of a Panx1 hemichannel protein or an amount of an antagonist of a Cx43 hemichannel protein.

Hemichannel extracellular-domain specific agents for treating ischemia-reperfusion injury

Hemichannel extracellular-domain specific agents for treating sepsis

Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and endotoxemia are also provided.

SAA-domain-specific antibodies and peptide antagonists and use thereof to treat inflammatory diseases

SAA domain-specific antibodies and peptide antagonists and use thereof to treat inflammatory diseases

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Plainview, NY, United States of America

Wei Li