University of Southern California

Wei Li

Mei Chen

David Woodley

Divya Sahu

Hangming Dong

Mengchen Zou

Chieh-Fang Cheng

David T Woodley

Described herein are compositions that include monoclonal antibodies that specifically bind Hsp90&#x3b1; and methods of using the same to treat HIF-1a-overexpressing cancer. In some embodiments, the cancers are breast cancer or lung cancer. The monoclonal antibodies bind the epitope TKPIWTRNP in Hsp90&#x3b1; or VKHFSVEGQ in Hsp90&#x3b1;.

Compositions and methods for treating HIF-1a over-expressing cancers

Described herein are compositions that include monoclonal antibodies that specifically bind Hsp90&#x3b1; and methods of using the same to treat HIF-1&#x3b1;-overexpressing cancer. In some embodiments, the cancers are breast cancer or lung cancer. The monoclonal antibodies bind the epitope TKPIWTRNP (SEQ ID NO: 1) in Hsp90&#x3b1; or VKHFSVEGQ (SEQ ID NO: 2) in Hsp90&#x3b1;.

Compositions and methods for treating HIF-1&#x3b1; over-expressing cancers

A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 &#x3bc;g/ml to about 100 &#x3bc;g/ml for a time sufficient to heal the wound is disclosed.

Methods of use of skin wound healing compositions

A wound healing composition comprising an amount of heat shock protein effective to promote wound healing and a method thereof to apply the composition. A preferred heat shock protein is either full-length hsp90&#x3b1; or the middle domain plus the charged sequence of hsp90&#x3b1;. The composition is topically applied to skin wounds, covering the outer surface of the wound. The heat shock protein acts by promoting migration of both human epidermal keratinocyte and dermal fibroblasts to the wound in order to close, heal, and remodel the wound.

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Altadena, CA, United States of America

Wei Li