China Medical University

Obi Pharma Inc.

Tsinghua University

Benq Corporation

Alliance Fiber Optic Products, Inc.

Chunghwa Telecom Co., Ltd.

Wei Lee

Woei-Cherng Shyu

Chang-Hai Tsai

Chen-Huan Lin

Chung-Y Hsu

Chia-Hung Hsieh

Long-Bin Jeng

Der-Yang Cho

San-Yuan Chen

Yih-Huang Hsieh

Yu-Hsin Lin

Sheng-Chu Kuo

Yu-Chen Lin

Cheng-Der Tony Yu

I-Ju Chen

Cheng-Chi Wang

Juei-Nai Kwo

Ming-Hwei Hong

Kuo-Hsiung Lee

Nan-Hsuan Wang

Yu Chen Lin

I-Fang Wu

Yi Jiun Lee

Chien-Lin Chen

Chung Hao Chang

Nan Hsuan Wang

Cheng Der Tony Yu

Yu Zhao

Yu-Chian Chen

Chun-Wei Chiang

Kun Yu Lee

Jen-Hao Yao

Bing-Hung Du

Feng-Peng Yu

Jui Yang Hung

Jin Rong Liang

Hsiang Pi Chang

Yan Dar Wu

A method for enhancing an expression of insulin like growth factor 1 receptor in an umbilical cord mesenchymal stem cell is provided. The method includes culturing the umbilical cord mesenchymal stem cell expressing insulin-like growth factor 1 receptor in a medium containing platelet-derived growth factor BB (PDGF-BB) to enhance the expression of insulin like growth factor 1 receptor in the umbilical cord mesenchymal stem cell.

Method for enhancing expression of insulin like growth factor 1 receptor in umbilical cord mesenchymal stem cell expressing IGF1R and method for obtaining multipotent umbilical cord mesenchymal stem cell

The present disclosure is related to the six isomer structures (OBI-821-1990-V1A, OBI-821-1990-V1B, OBI-821-1990-V2A, OBI-821-1990-V2B, OBI-821-1858-A, and OBI-821-1858-B) of isolated OBI-821 adjuvant and the method for evaluating the quality thereof. The method of the present disclosure adopts hydrophilic interaction liquid chromatography (HILIC) and reverse phase high performance liquid chromatography (RP-HPLC) either alone or in tandem and is able to separate the isomers of OBI-821 adjuvant in the consequent chromatography. Accordingly, the quality of OBI-821 adjuvant can be further evaluated.

Saponin adjuvant and evaluation method thereof

A method for enhancing an expression of insulin like growth factor 1 receptor in a mesenchymal stem cell is provided. The method includes culturing the mesenchymal stem cell expressing insulin-like growth factor 1 receptor in a medium containing platelet-derived growth factor BB (PDGF-BB) to enhance the expression of insulin like growth factor 1 receptor in the mesenchymal stem cell.

Method for enhancing expression of insulin like growth factor 1 receptor in mesenchymal stem cell, method for obtaining mesenchymal stem cell, and method for treating brain tissue damage

The present disclosure provides an engineered stem cell, comprising a vector comprising a polynucleotide comprising a nucleic acid sequence of suicide gene, a nucleic acid sequence of immune checkpoint gene and a natural cytotoxicity triggering receptor or a TNF-related apoptosis-inducing ligand, wherein the stem cell is a tumor-targeting cell. The present disclosure also provides a method for treating a cancer or enhancing intratumor immunity or enhancing immunity in tumor microenvironment in a subject, comprising administering an effective amount of the engineered stem cell of the present disclosure to the subject.

Engineering stem cells for cancer therapy

A method for treating a multiple sclerosis is provided. The method includes administering a composition containing a plurality of mesenchymal stem cells to a subject in need for a treatment of the multiple sclerosis, in which each of the mesenchymal stem cells expresses insulin-like growth factor 1 receptors.

Method for treating multiple sclerosis

A method for obtaining a plurality of pluripotent adult olfactory stem cells (APOSCs) includes isolating the APOSCs, culturing the isolated APOSCs in a sphere culture medium, and collecting the cultured APOSCs that express Bmi-1 (B-lymphoma moloney murine leukemia virus insertion region-1), Oct-4 (Octamer-binding transcription factor 4), Sox-2 (Sex-determining region Y (SRY)-box 2), Nanog, SSEA-4 (Stage-specific embryonic antigen-4), ki67, c-Myc, KLF-4 (Kruppel Like Factor 4), K14 (Cytokeratin 14) and ICAM-1 (Intercellular Adhesion Molecule 1).

Methods for obtaining pluripotent adult olfactory stem cells from an olfactory mucosa tissue

A composition including adult pluripotent olfactory stem cells is provided. The adult pluripotent olfactory stem cells are obtained by culturing a cell mixture from an olfactory tissue of a mammal in media containing growth factors and then isolating cells which express B-lymphoma moloney murine leukemia virus insertion region-1 (Bmi-1).

Methods for treating a brain tissue damage by cultured adult pluripotent olfactory stem cells

A method for enhancing an insulin like growth factorreceptor expression of a mesenchymal stem cell is provided. The method includes culturing a plurality of mesenchymal stem cells expressing insulin-like growth factorreceptors in media containing human cord blood serum to enhance the insulin like growth factorreceptor expression of the mesenchymal stem cells.

Method for enhancing insulin like growth factor 1 receptor expression of mesenchymal stem cell, method for isolating mesenchymal stem cell, and use of mesenchymal stem cell

The present invention provides vaccines comprising carbohydrate antigen conjugated to a diphtheria toxin (DT) as a carrier protein, wherein the ratio of the number of carbohydrate antigen molecule to the carrier protein molecule is higher than 5:1. Also disclosed herein is a novel saponin adjuvant and methods to inhibit cancer cells, by administering an effective amount of the vaccine disclose herein.

Vaccines with higher carbohydrate antigen density and novel saponin adjuvant

The present disclosure relates to a bicyclic compound, a pharmaceutical composition thereof, and its novel use. More particularly, the present disclosure relates to the bicyclic compound according to Formula I or Formula II, the pharmaceutical composition for treating a stroke, and the use of the bicyclic compound treating the stroke.

Bicyclic compound and pharmaceutical composition thereof for treating stroke and use thereof

A control system and protection method for integrated information security services are provided, which include protecting data packets of a user end device by a protecting device; generating an event log according to the protection result and transmitting the recorded event log to a collective control platform for standardizing and analyzing association by the collective control platform; detecting and transmitting abnormal information by the collective control platform to a service platform for integrating the information with network status information; displaying the integrated information on a webpage interface and transmitting the same to the user end device, thereby providing direct information on network security to save the high costs of purchasing, configuring and maintaining an information security protection system by the user.

Control system and protection method for integrated information security services

To minimize the space requirement inside a cassette and make cable retention force consistent and easy for fiber routing/rework, a cassette includes a cassette base molded to include a plurality of holders, a cassette cover to close the cassette base, and a plurality of blocks, respectively disposed into the holders, each of the blocks including one or more holes to accommodate one or more fiber cables. The fiber cables are fixed in the holes using a type of adhesive. In addition, bare fibers are placed inside the cassette to communicate respectively with the fiber cables.

Structured fiber optic cassette with multi-furcated cable access

The present invention provides a method for forming substrates for MOS (metal oxide semiconductor) transistor, comprising the following steps: (A) In a reduced-pressure environment having a pressure lower than 1&#xd7;10Torr, a base for accomplishing the surface reconstruction and a solid-state metal oxide source is provided, wherein the solid-state metal oxide source is chosen from the group consisting of the following: hafnium oxide, aluminum oxide, scandium oxide, yttrium oxide, titanium oxide, gallium gadolinium oxide and metal oxides of rare earth elements; and (B) vaporize the solid-state metal oxide source in order to make the solid-state metal oxide source become a metal oxide molecular beam and, in a working substrate temperature that is required to achieve an amorphous state of a first metal oxide film, deposit on the base having an amorphous state so as to further fabricate a substrate for MOS transistors.

Method for forming substrates for MOS transistor components and its products

An electronic device with retractable stylus. The electronic device comprises a main body and a stylus. The stylus comprises a resilient member disposed therein and a latching mechanism for engaging the main body. To connect the stylus and the main body, the resilient member is deformed and the latching mechanism is engaged with the main body. When the latching mechanism separates from the main body, the resilient member exerts force to extend the stylus to make the stylus protruded from the main body.

Electronic device with retractable stylus

Growing community of inventors

Taipei, Taiwan

Wei Lee