Siemens Healthcare Gmbh

Siemens Ag Osterreich

Wei Keat Lim

Dorin Comaniciu

Bogdan Georgescu

Ali Kamen

Tommaso Mansi

Andreas Keller

Xudong Zheng

Andreas Kremer

Cord Friedrich Staehler

Emil Wirsz

Vanessa King

A system operating in a plurality of modes to provide an integrated analysis of molecular data, imaging data, and clinical data associated with a patient includes a multi-scale model, a molecular model, and a linking component. The multi-scale model is configured to generate one or more estimated multi-scale parameters based on the clinical data and the imaging data when the system operates in a first mode, and generate a model of organ functionality based on one or more inferred multi-scale parameters when the system operates in a second mode. The molecular model is configured to generate one or more first molecular findings based on a molecular network analysis of the molecular data, wherein the molecular model is constrained by the estimated parameters when the system operates in the first mode. The linking component, which is operably coupled to the multi-scale model and the molecular model, is configured to transfer the estimated multi-scale parameters from the multi-scale model to the molecular model when the system operates in the first mode, and generate, using a machine learning process, the inferred multi-scale parameters based on the molecular findings when the system operates in the second mode.

System and methods for integrated and predictive analysis of molecular, imaging, and clinical data for patient-specific management of diseases

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Jersey City, NJ, United States of America

Wei Keat Lim