University of Missouri

Mitreoak, Ltd.

Wei Jia

Gary J Ehrhardt

Methods for the production of radionuclides suitable for use in radiopharmaceuticals for diagnostic and therapeutic applications, and specifically, to the production of,Re,,Re and other radionuclides such as,Pt and,Au using an inorganic Szilard-Chalmers reaction. Thin-film and powdered,Re,metal targets, and,Re oxide/metal oxide target compositions with rhenium in a lower, relatively reduced oxidation state are prepared. The thin-film rhenium targets are aged for at least about 24 hours and then irradiated with neutrons in the present of an oxidizing medium sufficient to form a product nuclide in the higher oxidized state of perrhenate, ReO,. Significantly, the rate and/or extent of oxidation of target nuclides which do not react with a neutron is controlled. For example, oxidation of such non-bombarded target nuclides is minimized by irradiating under vacuum, controlling the amount of oxidizing agent present, cooling during irradiation, etc. The product nuclide is recovered by dissolving the perrhenate in a non-oxidizing solvent such as water or saline.

Production of 186Re, 188Re and other radionuclides via inorganic Szilard-Chalmers process

A therapeutic composition and method of using the same for the palliation or relief of pain in patients having diseases which affect the bone and bone joints including metastatic bone cancer, arthritis, and other inflammatory arthropathies. The therapeutic composition comprises as the active agent a complex formed of non-radioactive metal ions and organic phosphonic acid ligands, or pharmaceutically acceptable salts thereof.

Composition and method for the palliation of pain associated with

Methods for the production of radionuclides suitable for use in radiopharmaceuticals for diagnostic and therapeutic applications, and specifically, to the production of .sup.186 Re, .sup.188 Re and other radionuclides such as .sup.195m Pt and .sup.198 Au using an inorganic Szilard-Chalmers reaction. Thin-film and powdered .sup.185 or 187 Re.degree. metal targets, and .sup.185 or 187 Re oxide/metal oxide target compositions with rhenium in a lower, relatively reduced oxidation state are prepared. The thin-film rhenium targets are aged for at least about 24 hours and then irradiated with neutrons in the present of an oxidizing medium sufficient to form a product nuclide in the higher oxidized state of perrhenate, ReO.sub.4.sup.-. Significantly, the rate and/or extent of oxidation of target nuclides which do not react with a neutron is controlled. For example, oxidation of such non-bombarded target nuclides is minimized by irradiating under vacuum, controlling the amount of oxidizing agent present, cooling during irradiation, etc. The product nuclide is recovered by dissolving the perrhenate in a non-oxidizing solvent such as water or saline.

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Columbia, MO, United States of America

Wei Jia