Naturewise Biotech and Medicals Corporation

Taipei Medical University

Academia Sinica

City of Hope

National Taiwan University

Fu Jen Catholic University

Gnt Biotech & Medicals Corporation

Wei-Jan Huang

Chia-Nan Chen

Li-Ling Chi

Chung-Yang Huang

Chia-Wei Lin

Ya-Huei Kuo

Yu-Chen Huang

Chung-I Chang

Wei-Jung Chen

Pi-Chuan Fan

Jing-Shi Huang

Ai-Ling Chen

Chi-Yun Lee

Lih-Chu Chiou

Ye-Su Chao

Yi-Hong Wu

Meng-Ju Tsai

Ching-Yi Lin

Hui-Ju Tseng

Wan-Yi Hsu

Yu-Jung Liao

Su-Jane Wang

Chih-Hsiang Huang

Chiou-Ping You

Huan-Yu Lin

Kai-Cheng Hsu

Liang-Chieh Chen

Ching-yi Lin

Chen Al-Ling

Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.

HDAC8 inhibitors for treating cancer

The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.

PH-sensitive linkers for delivering a therapeutic agent

Provided is a method for preparing hispidulin or a derivative thereof. The method includes selective protection of trihydroxybenzaldehyde, followed by regioselective iodination, selective protection, Stille coupling, Baeyer-Villiger oxidation and basic hydrolysis to obtain a protected intermediate compound. Then, alkylation, Claisen-Schmidt condensation, cyclization and deprotection of the protected intermediate compound are performed to obtain hispidulin or the derivative thereof. The present disclosure provides an efficient method for total synthesis of hispidulin or the derivative thereof with concise reaction steps and high yield.

Method for preparing hispidulin and its derivatives

The invention provides a method of changing a ratio of 68 to 64 kDa protein of MRJP3 in a royal jelly, a method of producing a royal jelly comprising MRJP3 having a changed ratio of 68 to 64 kDa protein relative to a control royal jelly and the royal jelly produced thereform. Also provided is a method of promoting the growth of the larva of a queen bee comprising feeding the larva of the queen bee a royal jelly of the invention. Further provided is a method of producing bee larva, pupa and queen bees with sizes larger than normal.

Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly

The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-cancer, anti-diabetic, and anti-neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Spinocerebellar Ataxias (SCA), and human spinal muscular atrophy (SMA).

Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase

The present invention relates to the use of a composition made fromfor treating tic disorder or sensorimotor gating deficits, wherein the composition is particularly made from the leaves of the plant.

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The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-neurodegenerative diseases and human spinal muscular atrophy (SMA).

Compounds for the inhibition of histone deacetylase

Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase

Growing community of inventors

Taipei, Taiwan

Wei-Jan Huang