Talari Networks, Inc.

Monogram Biosciences, Inc.

Oracle International Corporation

Laboratory Corporation of America Holdings

Wei Huang

Todd Martin

Sonia Kiang Rovner

Christos J Petropoulos

Neil T Parkin

Justin Allen Patterson

Jeannette Whitcomb

Wai Yee Lui

Jigar Mehta

Robert W Dickey, Iii

Jonathan D Klein

Adam Phillip Schultz

Christopher Wayne Parsons

Douglas Richman

Mary T Wrin

Susan Little

Jeanette Whitcomb

Anthony Matteo Gallo

Stephen Craig Connors, Jr

Signe Fransen

Jonathan Toma

William H Waddington

Roger J Bamford

Boris Klots

Gary C Ngai

Dinesh Das

Cheryl Lynn Adams

Gianfranco Putzolu

Bhagat V Nainani

Alexander C Ho

Larry Stevens

Paul D Worley

Jeanette M Whitcomb

Jeannette M Whitcomb

Systems and techniques, including special messages and state machines, are described that configures an intermediate site to dynamically trigger creation of and removal of a dynamic conduit between two sites based on usage that is tracked at the sites. The intermediate site providing WAN-to-WAN forwarding between the two sites, monitors throughput statistics on each local WAN link (LWL) associated with the two sites. If traffic between the two sites passes a configured first threshold or if LWL usage passes a configured second threshold, the intermediate site sends a message to the two sites to set up a dynamic conduit directly coupling the two sites. Busy lists are used to keep track of eligible site pairs. Once a dynamic conduit is set up between two sites, a grow technique tests the dynamic conduit increasing communication flows between the two sites each configured sampling period before putting the conduit in normal use.

Adaptive private network with dynamic conduit process

Techniques are described to automatically activate and deactivate standby backup paths in response to changing bandwidth requirements in an adaptive private network (APN). The APN includes one or more regular active wide area network (WAN) links in an active mode and an on-demand WAN link in a standby mode. The on-demand WAN link is activated to supplement the conduit bandwidth when an available bandwidth of the conduit falls below a pre-specified trigger bandwidth threshold and the conduit bandwidth usage exceeds a usage threshold of a bandwidth of the conduit that is being supplied by the active paths (BWc). The on-demand WAN link is deactivated to standby mode when an available bandwidth of the conduit is above the pre-specified trigger bandwidth threshold and the conduit bandwidth usage drops below the usage threshold of BWc techniques for adaptive and active bandwidth testing of WAN links in an APN are also described.

Adaptive private network (APN) bandwidth enhancements

System and techniques are described which apply a method for automatic database schema migration. An initial database is installed, according to rules that define tables of data, in an adaptive private network (APN) having a centralized management system including a network control node (NCN) coupled through the APN to a plurality of client nodes, wherein the NCN provides timing and control to the client nodes. An update to the initial database is received, wherein the initial database includes a first table of data stored in a first set of columns and the updated database includes a modified first table having a second set of columns that has a different number of columns as compared to the first table is automatically detected. One or more columns from the second set of columns that are different than the first set of columns are updated for data content.

Methods and apparatus for providing adaptive private network database schema migration and management processes

The invention provides a method for treating a patient having human immunodeficiency virus (HIV) infection by determining whether the human immunodeficiency virus is likely to be more resistant to a viral entry inhibitor than a reference HIV and treating the patient based on that determination. In certain aspects, the methods comprise detecting whether the envelope protein from an HIV from the patient comprises a mutation or mutations in codons 117, 421, 121, and/or 298, wherein the presence of the mutation or mutations indicates that the HIV is likely to be more susceptible to the entry inhibitor than the reference HIV.

Methods for determining resistance or susceptibility to HIV entry inhibitors

Systems and techniques are described for a path maximum transmission unit (MTU) discovery method that allows the sender of IP packets to discover the MTU of packets that it is sending over a conduit to a given destination. The MTU is the largest packet that can be sent through the network along a path without requiring fragmentation. The path MTU discovery method actively probes each sending path of each conduit with fragmentation enabled to determine a current MTU and accordingly increase or decrease the conduit MTU. The path MTU discovery process is resilient to errors and supports retransmission if packets are lost in the discovery process. The path MTU discovery process is dynamically adjusted at a periodic rate to adjust to varying network conditions.

Adaptive private network with path maximum transmission unit (MTU) discovery process

A method for managing multiple software defined wide area network (SD-WAN) software versions includes providing a controller that defines an overall configuration for an SD-WAN and that creates configuration registries for individual SD-WAN appliances to implement their respective portions of the overall configuration. The controller generates, in an intermediate configuration language registry format, a first and second configuration registry for first and second SD-WAN appliance that respectively execute first and second versions of SD-WAN software. The controller respectively transmits the first and second configuration registries to the first and second SD-WAN appliances, which use the first and second configuration registries to configure themselves. The first and second SD-WAN appliances negotiate with each other for common SD-WAN features usable to implement configurations specified in the first and second configuration registries.

Methods, systems, and computer readable media for managing multiple software defined wide area network (SD-WAN) software versions

Techniques for providing a backup network path using a standby wide area network (WAN) link with reducing monitoring. Packet loss and latency metrics are monitored for network paths in an adaptive private network (APN) connecting a first user and a second user according to control traffic operating at a first control bandwidth for each network path. A determination is made that a first network path uses a standby WAN link, has packet loss and latency metrics indicative of a good quality state, and has at least one characteristic that identifies the first network path as a backup network path. The control traffic is then reduced for the backup network path to a second control bandwidth substantially less than the first control bandwidth. The backup network path is made active when the number of active network paths is less than or equal to a minimum number.

Methods and apparatus for configuring a standby WAN link in an adaptive private network

Techniques are described to automatically activate and deactivate standby backup paths in response to changing bandwidth requirements in an adaptive private network (APN). The APN is configured with one or more regular active wide area network (WAN) links in an active mode and an on-demand WAN link in a standby mode. The on-demand WAN link is activated to supplement the conduit bandwidth when an available bandwidth of the conduit falls below a pre-specified trigger bandwidth threshold and the conduit bandwidth usage exceeds a usage threshold of a bandwidth of the conduit that is being supplied by the active paths (BW). The on-demand WAN link is deactivated to standby mode when an available bandwidth of the conduit is above the pre-specified trigger bandwidth threshold and the conduit bandwidth usage drops below the usage threshold of BW. Techniques for adaptive and active bandwidth testing of WAN links in an APN are also described.

Adaptive private network (APN) bandwith enhancements

The invention provides a method for determining whether a human immunodeficiency virus is likely to be more resistant to a viral entry inhibitor than a reference HIV. In certain aspects, the methods comprise comparing the length of one or more variable regions of an envelope protein of the HIV or a number of glycosylation sites on the envelope protein of the HIV to a length of one or more corresponding variable regions of an envelope protein of the reference HIV or a number of glycosylation sites on the envelope protein of the reference HIV, wherein the HIV is likely to be more resistant to the CD4 binding site entry inhibitor than the reference HIV when the HIV has longer variable regions than the reference HIV or the HIV has more glycosylation sites than the reference HIV.

The present invention provides methods and compositions for determining whether a subject would benefit from co-receptor inhibitor therapy. In certain aspects, the methods can be used to determine whether a subject infected with a dual-mixed tropic population of HIV would benefit from CCCR5-inhibitor therapy or CXCR4-inhibitor therapy, the methods comprising determining whether the HIV population is a homogeneous or heterogeneous population of HIV, wherein the nature of the homogenous or heterogenous population of HIV indicates whether the patient would benefit from co-receptor inhibitor therapy.

Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy

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Foster City, CA, United States of America

Wei Huang