University of California

Wei Gao

Joseph Wang

Sirilak Sattayasamitsathit

Emilia S Olson

Robert Mattrey

Zhe Wu

Christopher D Malone

Methods, structures, devices and systems are disclosed for fabrication of microtube engines using membrane template electrodeposition. Such nanomotors operate based on bubble-induced propulsion in biological fluids and salt-rich environments. In one aspect, fabricating microengines includes depositing a polymer layer on a membrane template, depositing a conductive metal layer on the polymer layer, and dissolving the membrane template to release the multilayer microtubes.

Membrane template synthesis of microtube engines

A method and system are provided for detection of localized hydrogen peroxide within tissue by introducing a catalase-containing material into at location of interest, positioning an ultrasound transducer over the location, and generating an ultrasound image to detect microbubbles, where the presence of microbubbles indicate the presence of localized hydrogen peroxide. The catalase-coated surface may be the inner surface of a microtube, on the surface of or incorporated within a nanosphere or microsphere, or an implantable device.

Method and system for in vivo hydrogen peroxide detection with ultrasound

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La Jolla, CA, United States of America

Wei Gao