National Taiwan Normal University

Pharmaessentia Corporation

Wei-Der Lee

Kwunmin Chen

Wensen Li

Kung-Shou Yang

Chi-Yuan Chu

Chan Kou Hwang

Jia-Fu Pan

This invention relates to a process of stereoselectively synthesizing a &#x3b2;-nucleoside compound of formula (I): wherein R, R, and B are as defined in the specification; each of Rand R, independently, is H or fluoro. The process includes reacting, in the presence of a transition metal salt, a tetrahydrofuran compound of formula (II): wherein R, R, and L are as defined in the specification, with a nucleobase derivative; and each of Rand R, independently, is H or fluoro.

Synthesis of &#x3b2;-nucleosides

Chiral chelating agents and chiral catalysts, which are formed from the chiral chelating agents and metal, are described. One chiral chelating agent has a general formula (1) as illustrated below:wherein R represents H, methyl, ethyl, a primary, secondary or tertiary straight, branched or cyclic alkyl group having 3-7 carbon atoms, a heterocyclic or aromatic group, an aromatic group substituted at the 2-, 3- or 4-position, an aromatic-like group, or a naphthyl or naphthyl-derived group, and n is an integer between 0 and 4.

Chiral cheating agent and chiral catalyst

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Kaohsiung, Taiwan

Wei-Der Lee