Massachusetts Institute of Technology

Schlumberger Technology Corporation

Wei-Chuan Shih

Oliver Clinton Mullins

Michael S Feld

Albert Ballard Andrews

Matthew Clayton

George Barbastathis

Chee Wei Wong

Sang-Gook Kim

Martin Hunter

Thomas Scecina

Annika Enejder

Kate Bechtel

Yong-Bae Jeon

The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.

Intrinsic Raman spectroscopy

The invention relates to a method for detecting the presence of hydrocarbons near an unmanned offshore oil platform. The method steps include monitoring reflected atmospheric and thermal radiation, detecting the presence of hydrocarbons, and generating an alert based on the presence of hydrocarbons.

Method and apparatus for oil spill detection

The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.

Raman spectroscopy for non-invasive glucose measurements

A volume diffractive composite is disclosed for providing illumination at a first output angle. The volume diffractive composite comprises a first plurality of grating elements that are mutually spaced from another in a first position with a first spacing period along a first plane, and an actuation unit for changing at least one of the position or the spacing period of the first plurality of grating elements to a second position or spacing period to provide illumination at a second output angle.

Micro-actuated adaptive diffractive composites

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Cambridge, MA, United States of America

Wei-Chuan Shih