Grape King Bio Ltd

Wei-Ching Chu

Chien-Chih Chen

Chin-Chu Chen

Ting-Wei Lin

Li-Ya Lee

Jui-Hsia Hsu

Wan-Ping Chen

Pei-Shan Liu

The present invention is related to an active substance ofhaving a pain-relieving effect, and a pharmaceutical composition including the active substance. The active substance is prepared using the following steps: (a) inoculating a mycelium ofon an agar plate and incubating at 15-32&#xb0; C. for 8-16 days; (b) inoculating the incubatedmycelia from step (a) into a medium in a flask and incubating at 20-30&#xb0; C. and pH 4.5-6.5 for 3-5 days; (c) inoculating the incubatedmycelia from step (b) into a medium in a fermentation tank and incubating at 24-32&#xb0; C. and pH 4.5-5.5 for 8-16 days to obtain a fermented medium of themycelia; and (d) desiccating the fermented medium of themycelia from step (c) to obtain the powder of themycelia, which is further purified and isolated to obtain a novel compound of

Heripenes with pain-relieving effect, active substances ofmycelium and the preparation method thereof, and pharmaceutical composition containing the heripenes or active substances

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Taoyuan, Taiwan

Wei-Ching Chu