Arbor Biotechnologies, Inc.

Wei-Cheng Lu

Shaorong Chong

Quinton Norman Wessells

Anthony James Garrity

Brendan Jay Hilbert

Tia Marie Ditommaso

Lauren E Alfonse

The present invention relates to variant polypeptides, methods of preparing the variant polypeptides, processes for characterizing the variant polypeptides, compositions and cells comprising the variant polypeptides, and methods of using the variant polypeptides. The invention further relates to complexes comprising the variant polypeptides, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.

Compositions comprising a variant polypeptide and uses thereof

The present invention relates to variant Cas12i4 polypeptides, methods of producing the variant Cas12i4 polypeptides, processes for characterizing the variant Cas12i4 polypeptides, cells comprising the variant Cas12i4 polypeptides, and methods of using the variant Cas12i4 polypeptides. The invention further relates to complexes comprising a variant Cas12i4 polypeptide and an RNA guide, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.

Compositions comprising a variant Cas12i4 polypeptide and uses thereof

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Cambridge, MA, United States of America

Wei-Cheng Lu