Wenzhou University

Youvision Biotech Co., Ltd.

Eye Hospital, Wenzhou Medical University

Wei Chen

Liang Shu

Dingfang Chen

Guichu Wu

Ziran Wu

Miao Yang

Yongliang Lin

Xu Zhang

Jie Zhang

Qinxiang Zhen

Yanfang Yang

Qinxiang Zheng

Jun Yang

Disclosed is a montelukast berberine double salt or composition with anti-inflammatory, antibacterial and immunomodulatory effects. Particularly, disclosed are a montelukast berberine quaternary ammonium salt with a structure as represented by formula (I), a double salt or a composition, a solvate, a hydrate, an isotope substitution or an isomer thereof.

Montelukast berberine quaternary ammonium salt compound and double salt composition, and synthesis method therefor and use thereof

A digital-twin modeling method for an automated testing pipeline for circuit breakers involves acquiring a three-dimensional digitalized model of each mechanical installation in the testing pipeline; modeling hierarchy according to an actual production process and motion states; performing mesh optimization on the resulting model; designing movements of each said mechanical installation, so as to obtain mechanical movement tracks of the models; combining actual movement logic and cooperative relationship among the movements to edit the mechanical movement tracks of the models; and introducing motion control, so as to conduct motion simulation in a digital-twin scene, thereby implementing virtual movements synchronous with movements of the actual testing pipeline. The method realizes centralized management of production data of the pipeline and realizes remote visualized operation, management and maintenance of the testing pipeline, thereby providing a basic platform for digitalized production of miniature circuit breakers.

Digital-twin modeling method for automated testing pipeline for circuit breakers

Disclosed is a method for preparing a heterogenous corneal material, wherein during the whole preparation process, different concentrations of glycerol are used to achieve that the heterogenous corneal graft has the transparent, properties of no viruses and cells; resistance to degradation and immunogenicity of collagen can be further reduced by collagen cross-linking; and under the whole eye saving, cross-linkers 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and N-hydroxy sulfosuccinimide (NHS) are used for cross-linking, thus enabling the form thereof to be closer to that of a fresh cornea and improving biomechanical properties thereof. The method can prepare a heterogenous corneal material with a high transparency, a low immunogenicity and a good bioactivity and biocompatibility, and can maintain that the three-dimensional structure of collagen is close to that of a fresh cornea. The corneal material prepared by the method is improved in both saving of fibre structure of corneal collagen and transparent performance after transplantation and can be widely used in the medical field.

Method for preparing heterogenetic corneal material

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Wenzhou, China

Wei Chen