Washington State University

Wei Chen

Ming Xian

Reactive sulfur species have been recognized as an important regulator in redox biology, wherein the reactive sulfur species have been shown to be active in tumor suppressors, ion channels, and transcription factors. The disclosed invention is a novel composition of matter that allows for the detection of HS and HSspecies in living cells. These novel compositions represent significant progress in the field of chemical, HS and HSprobes as they have both been successfully applied in the visualization sulfur species in living systems.

Fluorescent probes for detecting hydrogen polysulfides

Reaction-based fluorescent probes are provided which detect, for example, biologically important sulfane sulfur species (persulfide, polysulfide, and elemental sulfur) in, for example, complex and living systems. The probes are high in selectivity and sensitivity to sulfane sulfurs. Moreover, probes are suitable for bioimaging sulfane sulfurs in living cells.

Growing community of inventors

Pullman, WA, United States of America

Wei Chen