Dell Products Inc.

Lanova Medicines Limited

Gracell Biotechnologies (shanghai) Co., Ltd.

Suzhou Gracell Biotechnologies Co., Ltd.

Baoshan Iron & Steel Co., Ltd.

Shanghai Research Center for Wireless Communications

Cellular Biomedicine Group Hk Limited

Cellular Biomedicine Group, Inc.

Wei Cao

Yu Zhang

Hong Li

Hao Wang

Feng Zhang

Bo Wang

Yujie Zhou

Honglin Hu

Runsheng Li

Wentao Huang

Jing Sun

Shishu Xie

Huawei Zhang

Hongxu Hei

Aihua Ma

Liping Liu

Xiandong Liu

Liang Zou

Hua Qian

Kshitij Patel

Ying Qin Zang

Xinxin Wang

Yezhong Sun

Changsong Ma

Jianru Zhu

Mohammad Abdul Kaium

Xiaoling Zeng

Chunhui Yang

Zhongdong Shi

Zhuolei Chen

Tao Jin

Shuyi Qiu

Xueyun Li

Nicholas Chun Wei

Songbai Cai

Junliang Liu

Helen Zhang

Xiao Chen

Luyi Zhang

The present disclosure relates to an engineered immune cell and use thereof. The present disclosure provides an engineered immune cell comprising a CAR or engineered TCR, which CAR or engineered TCR can comprise a first antigen binding domain and a second antigen binding domain. The engineered immune cells of the present disclosure, when administered into a subject, can inhibit the host immune cells such as T cells and/or NK cells and enhance the survival and persistence of the engineered immune cells in vivo, thereby exhibiting more effective tumor killing activity.

Compositions and methods for T cell engineering

Provided are bispecific or multispecific antibodies that include an anti-CEACAM5 portion and one or more anti-4-1BB nanobodies whose agonist activity is dependent on the presence of the CEACAM5 antigen. Such bispecific or multispecific antibodies are safe, and are efficacious in treating cancer and have long-term protective immunological memory against tumors. Methods of using the antibodies for treating diseases such as cancer are also provided.

CEACAM5-dependent 4-1BB-agonistic bispecific antibodies

Methods, apparatus, and processor-readable storage media for efficient storage of key-value data with schema integration are provided herein. An example computer-implemented method includes obtaining a metrics data message associated with a product, wherein the metrics data message has a first format and comprises a schema version and a type of the product; identifying one of a plurality of schema definitions for the metrics data message based at least in part on the schema version and the type of the product; converting the metrics data message into a second format based on the identified schema definition, wherein the second format removes at least some redundant data from the metrics data message; and storing the converted metrics data message in a metrics database.

Efficient storage of key-value data with schema integration

Growing community of inventors

Shanghai, China

Wei Cao