Abbott Laboratories Corporation

Wei-Bo Wang

Qun Li

Daniel T Chu

Lisa A Hasvold

Jacob J Plattner

Hing L Sham

Xilu Wang

Le Wang

Gary T Wang

Nan-Horng Lin

Gerard M Sullivan

Zhenkun Ma

Todd Warren Rockway

Robert A Mantei

Anthony K Fung

Tongmei Li

Yunsong Tong

Curt S Cooper

Cheuk M Lee

Stephen L Gwaltney, Ii

Akiyo K Claiborne

Francis A Kerdesky

Chi-nung W Hsiao

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formulaare useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.

Process for preparation of chiral 3-amino-pyrrolidine and analogous

Antibacterial compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds wherein

Quinolizinone type compounds

A process for the preparation of a compound having the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid

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Grayslake, IL, United States of America

Wei-Bo Wang