Sanofi-a Ventis Deutschland Gmbh

Millennium Pharmaceuticals Limited

Aventis Pharma Deutschland, Gmbh

Wayne William Hancock

Alfredo C Castro

Louis Grenier

Julian Adams

Francois Soucy

Olaf Ritzeler

Vito J Palombella

Hormoz Mazdiyasni

Engin Ozkaynak

Hormoz Mazdiyashi

The subject matter of the present invention is directed to novel substituted &#x3b2;-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I&#x3ba;B kinase is involved.

Substituted &#x3b2;-carbolines

The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I,which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I&#x3ba;B kinase is involved.

Substituted beta-carbolines

Substituted beta carbolines

The present invention relates to methods for identifying compounds that can reduce immune rejection, for example, transplant- or autoimmune disorder-related immune rejection. The present invention is based, in part, on the discovery, demonstrated herein, that immune rejection can be monitored by determining the amount of particular members of the Jak/Stat signal transduction pathway present within an affected tissue. The present invention is further based, in part, on the discovery, demonstrated herein, that immune rejection can be reduced and tolerance can be induced by modulating the amount of these particular members of the Jak/Stat signal transduction pathway present, expressed or active within an affected tissue. In particular, the results demonstrate that immune rejection can be monitored by determining the amount of mRNA or protein of Stat , Stat , Stat , Stat , SOCS , or SOCS present, e.g., in an affected tissue.

Method for identifying a compound to be tested for an ability to reduce immune rejection by determining Stat4 and Stat6 proteins

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Medfield, MA, United States of America

Wayne William Hancock