The Children's Hospital of Philadelphia

University of Illinois

University of Pennsylvania

Progenra, Inc.

Sanofi-a Ventis Deutschland Gmbh

Wayne W Hancock

Alfredo C Castro

Alan P Kozikowski

Mark I Greene

Joseph Weinstock

Louis Grenier

Julian Adams

Francois Soucy

Olaf Ritzeler

Hormoz Mazdiyasni

Joel Bergman

Jay Hans Kalin

Kyle Vincent Butler

Suresh Kumar Kizhakkethil-George

Feng Wang

Jian Wu

Matthew P Kodrasov

Saket Agarwal

Yan Xiao

Makoto Katsumata

Vito Palombella

Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

HDAC inhibitors and therapeutic methods using the same

Methods and compounds for treating cancer by, for example, modulating immune system activity, are provided.

Methods of treating cancer through the inhibition of USP7 and immune system modulation

This invention is in the fields of immunology and autoimmunity. More particularly it concerns methods of treating patients with compounds which are useful agents for inhibiting the functions of TIP60 in the treatment of an individual suffering, for example, from ulcerative colitis and other irritable bowel diseases.

Therapy of autoimmune colitis using a TIP60 inhibitor

Growing community of inventors

Philadelphia, PA, United States of America

Wayne W Hancock