Immulogic Pharmaceutical Corporation

Merck Patent Gmbh

Phylogica Limited

Immulogic Pharmaceuticals, Inc.

Other

Heska Corporation

The Institute of Child Health Research

The Institute for Child Health Research

Immulogic Pharmaceutical Co.

Wayne Robert Thomas

Kaw-Yan Chua

Richard John Simpson

Geoffrey Alexander Stewart

Keven J Turner

Mei-chang Kuo

Bruce L Rogers

Paul Michael Watt

Richard Hopkins

Isolated nucleic acids encoding an allergen of, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

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Isolated nucleic acids encoding an allergen of,III, are disclosed. A cDNA encoding a peptide having aIII activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence ofIII nucleic acid in a sample or for the recombinant production of peptides having an activity ofIII. Peptides having an activity ofIII can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

Isolated nucleic acids encoding allergens of the speciesand, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acids of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleic acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.

Nucleic acid molecules encoding a house dust mite allergen Der f VII, and antigenic peptides thereof

The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid.

Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom

The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid fragments of the libraries are derived from two or more diverse characterized genomes.

Methods of constructing and screening diverse expression libraries

The present invention provides a method for identifying a modulator or mediator of a biological activity, which activity includes antigenicity and or immunogenicity, said method comprising the step of:

Isolating biological modulators from biodiverse gene fragment libraries

Isolated nucleic acids encoding allergens of the speciesandDer p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acid of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleotide acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.

House dust mite allergen, Der f VII, and uses therefor

A novel protein allergen Der p VII ofis described. A cDNA clone encoding Der p VII was isolated from a &#x3bb;gt11 library ofcDNA. The nucleic acid sequence of Der p VII encodes a 198 residue mature processed protein having a predicted molecular weight of 22,177 daltons. Der p VII protein may be used as the active ingredient in therapeutic composition for the treatment of sensitivity to house dust mites. The protein may also be used in methods of diagnosing such sensitivity.

Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor

Isolated nucleic acids encoding an allergen of III, are disclosed. A cDNA encoding a peptide having a III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of III nucleic acid in a sample or for the recombinant production of peptides having an activity of III. Peptides having an activity of III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

Nucleic acids encoding a house dust mite allergen Der p III, and uses therefor

Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species and , which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major allergens, I and II and DNA encoding a allergen, I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.

Cloning and sequencing of allergens of dermatophagoides

Cloning and sequencing of allergens of dermatophagoides house dust mite

Isolated nucleic acids encoding allergens of the species and , Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acids of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleic acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.

Isolated nucleic acids encoding an allergen of,III, are disclosed. A cDNA encoding a peptide having a,III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of,III nucleic acid in a sample or for the recombinant production of peptides having an activity of,III. Peptides having an activity of,III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

Nucleic acids encoding a house dust mite allergen, Der p III, and uses therefor

Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronyssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.

Growing community of inventors

Nedlands, Australia

Wayne Robert Thomas