Zymogenetics, Inc.

Elwha LLC

The Invention Science Fund I LLC

Kota Biotherapeutics, LLC

Other

Anergen, Inc.

Bristol-myers Squibb Compnay

Novo Nordisk A/s

Wayne R Kindsvogel

Roderick A Hyde

Wenfeng Xu

Scott R Presnell

Zhi Chen

Kevin M Klucher

Paul O Sheppard

Pallavur V Sivakumar

Brian A Fox

Yasmin A Chandrasekher

David W Taft

Steven D Hughes

Elizabeth A Sweeney

Gary L McKnight

Andrzej Z Sledziewski

Lillian Anne Bell

Stacey R Dillon

Anthony W Siadak

Margaret Dow Moore

Joyce M Lehner

Jordin T Kare

Mahalaxmi Gita Bangera

William David Duncan

Francis J Grant

Laura J Jelinek

Lowell L Wood, Jr

Charles Whitmer

Katherine E Henderson

Donald C Foster

Joseph Leon Kuijper

Chung Chan

Si Lok

Patrick J O'Hara

Sean E Doyle

Clarence T Tegreene

Nathan P Myhrvold

Mark A Malamud

Royce A Levien

Darrell C Conklin

James M LaGasse

Edward K Y Jung

Philip Andrew Eckhoff

Julia E Novak

Eleanor V Goodall

Mark W Rixon

Erez Lieberman

John M Maraganore

Jane A Gross

Richard D Holly

Stavros Topouzis

Andrew J Nelson

Theodore E Whitmore

William Hagopian

Christopher H Clegg

Pallavar V Sivakumar

William A Hagopian

Eva Pia Reich

Mark D Heipel

Rebecca A Johnson

Patrick J O'hara

Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin capable of binding to a first antigen and at least one endogenous secreted immunoglobulin capable of binding to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.

Compositions and methods for modified b cells expressing reassigned biological agents

Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.

Compositions and methods including cytotoxic B lymphocyte cell line expressing exogenous membrane immunoglobulin different from secreted immunoglobulin

Breast monitoring systems are described including a breast sensor device having a substrate fabricated to substantially conform to one or more breasts of a subject, dynamically bendable optical fibers, and a connector; a light source configured to operably couple with the optical fibers through the connector; a photodetector configured to operably couple with the optical fibers through the connector and positioned to detect light transmission through the optical fibers; a reporting device; and a microcontroller including a microprocessor and circuitry, the circuitry including input circuitry configured to receive a first set of signals and at least one second set of signals from the photodetector; calculation circuitry configured to calculate a curvature delta value based on a comparison of the first and at least one second set of signals, and calculate a breast volume delta value from the calculated curvature delta value; and reporting circuitry.

Systems, devices and methods for monitoring breastfeeding

Compositions and methods for modified B cells expressing reassigned biological agents

Breast monitoring systems and methods are described including a flexible substrate fabricated to substantially conform to one or more breasts of a subject; dynamically bendable optical fibers associated with the flexible substrate; a light source operably coupled to the optical fibers; a photodetector positioned to detect light reception from the optical fibers; a reporting device; and a microcontroller including a microprocessor and circuitry, wherein the circuitry includes input circuitry configured to receive a first set of signals and at least one second set of signals from the photodetector; calculation circuitry configured to calculate a curvature delta value based on a comparison of the received first and at least one second set of signals, and calculate a breast volume delta value from the calculated curvature delta value; and reporting circuitry configured to transmit a signal to the reporting device based on the calculated breast volume delta value.

A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including a layered wall, the flexible tubular structure including a plurality of at least one type of commensal microbe encased in the layered wall, the layered wall configured to allow an interaction between the plurality of the at least one type of commensal microbe and an ingested product within the flexible tubular structure, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.

Gastrointestinal device with associated commensal microbes

A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including a layered wall, the flexible tubular structure including at least one microbe-promoting agent encased in the layered wall, the microbe-promoting agent configured to promote at least one of attraction, colonization, and growth of at least one type of commensal microbe, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.

Gastrointestinal device with associated microbe-promoting agents

Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated B lymphocyte cell line. An isolated recombinant cell line includes an isolated B lymphocyte cell line capable of expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and at least one exogenously incorporated nucleic acid encoding at least one secreted immunoglobulin reactive to a second antigen.

Compositions and methods including recombinant B lymphocyte cell line including at least one endogenous gene expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and including at least one exogenously incorporated nucleic acid expressing at least one exogenous secreted immunoglobulin reactive to a second antigen

Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen.

Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen

A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including an inner surface and an outer surface, a plurality of at least one type of commensal microbe associated with at least a portion of at least one of the inner surface and the outer surface, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.

A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including an inner surface and an outer surface, at least one microbe-promoting agent associated with at least one of the inner surface and the outer surface, the at least one microbe-promoting agent configured to promote attraction, colonization, and growth of at least one type of commensal microbe, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.

Various embodiments disclosed herein include systems, methods, compositions, and products by process for Rapid-breeding of plants. In certain embodiments, the systems and/or methods are at least partially automated.

Rapid breeding of plants

Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subject's own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.

Compositions, methods, and computer systems related to making and administering modified T cells

Growing community of inventors

Seattle, WA, United States of America

Wayne R Kindsvogel