University of Colorado

Wayne Minobe

Michael R Bristow

Leslie A Leinwand

Koichi Nakao

Koichiro Kinugawa

The invention provides a method of treating myocardial failure in a human. The method comprises administering an effective amount of transgene encoding &#x3b1;-MHC that directly causes an increase in the quantity of &#x3b1;-MHC in the myocardial tissue of the heart.

Diagnosis and treatment of myocardial failure

The present invention provides methods of diagnosing myocardial failure in a human. The methods comprise obtaining a sample of myocardial tissue from a ventricle of the heart. In one embodiment, the expression of &#x3b1;-myosin heavy chain, &#x3b2;-myosin heavy chain, or both, are quantitated and their expression levels compared to that seen normal human ventricular myocardial tissues. In another embodiment, the expression of &#x3b1;1-thyroid hormone receptor, &#x3b1;2-thyroid hormone receptor, a &#x3b1;1-thyroid hormone receptor+&#x3b2;1-thyroid hormone receptor, or combinations thereof, are quantitated, and their expression levels compared to that seen normal human ventricular myocardial tissues. Therapeutic interventions based on altering the expression of the aforementioned genes also are provide.

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Golden, CO, United States of America

Wayne Minobe