Gene Shears Pty. Limited

Tasmanian Alkaloids Pty. Ltd.

Johnson & Johnson Research Pty Limited

Wayne Lyle Gerlach

Fiona Helen Cameron

Philip Anthony Jennings

James Phillip Haseloff

Anthony John Fist

Christopher James Byrne

Geoffrey Phillip Symonds

Lun-Quan Sun

Rafael G Amado

Gregory C Fanning

Janet L MacPherson

Janet Lesley Macpherson

David G Atkins

Greg Fanning

Mark J Young

Geoffery P Symonds

There is disclosed an improved poppy straw of a stably reproducing Papaver somniferum for the extraction of thebaine and/or oripavine, the threshed straw having thebaine and oripavine constituting about 50% by weight or greater of the alkaloid combination consisting of morphine, codeine, thebaine and oripavine.

Production of thebaine and oripavine

Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection.

Process for the preparation of a composition of genetically modified hematopoietic progenitor cells

Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells

The invention consists of a non-naturally occurring nucleic acid molecule capable of blocking or interfering with a replicative intermediate of a virus, a virusoid, or a viroid. The nucleic acid molecule may contain a ribozyme or a plurality of ribozymes. Alternatively, the nucleic acid molecule may be an antisense nucleic acid molecule. The ribozyme may be a hairpin ribozyme, a hammerhead ribozyme, an RNAase P ribozyme, a minizyme, or other catalytic RNA molecule. The virus may be an animal, a mammalian, a plant, a fungal, a protozoan, a yeast, a bacterial virus, or a human virus. The nucleic acid molecule may be expressed in the cell or it may be preformed and administered ex vivo. The present invention contemplates methods of controlling infection of a pathogenic infectious agent in a plant or animal.

Ribozyme nucleic acids and methods of use thereof for controlling viral pathogens

Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a plant, animal or viral target RNA, a region of defined sequence and a base paired stem region.

Ribozymes

Papaver somniferum strain with high concentration of thebaine and

Hammerhand ribozymes

Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise nucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.

Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.

Growing community of inventors

Hughes, Australia

Wayne Lyle Gerlach