The State University of New York

Wayne K Anderson

Quanxi Jia

Rudiger D Haugwitz

Franklyn M Collins

Hoong J Lee

Kaili Jiao

Dennis C Dean

Dominick A Quagliato

In a first embodiment of the invention a layer of ruthenium oxide is reactively deposited onto a substrate, then annealed for TCR adjustment and for stabilization. In a second, bi-layer embodiment of the invention, a layer of tantalum nitride is first reactively deposited onto a substrate, then annealed for stabilization. After a ruthenium oxide layer is reactively deposited onto the annealed tantalum nitride layer, the structure is annealed until a near-zero effective TCR for the bi-layer resistor is achieved. The ruthenium oxide capping layer serves as a barrier against chemical attack.

Thin film resistors comprising ruthenium oxide

This invention relates to new pyridyl, quinoline and acridine bis-acyloxymethyl compounds; to compositions comprising these compounds; and to processes for their utility as fungicides, bactericides and as inhibitors of the growth of cancer in warm-blooded animals. In accordance with this invention, new bis-acyloxymethyl derivatives are provided of the formula: ##STR1## wherein B is selected from substituted and unsubstituted alkyl, cycloalkyl, aryl, alkenyl, cycloalkenyl and alkynyl; A is selected from hydrogen and B; or, A and B together comprise a pyrrolizine; L is selected from ##STR2## wherein Y is selected from hydrogen or ##STR3## each R and Z is independently selected from hydrogen or substituted and unsubstituted alkyl, cycloalkyl, aryl, alkenyl, cycloalkenyl, alkynyl, amine group, each Z' is independently selected from hydrogen and substituted or unsubstituted alkyl; M is Z or is selected from halogen, nitro, hydroxyl, nitrile and substituted or unsubstituted, carboxylic acid group, carboxylic acid ester group, carboxylic acid amide group, sulfonic acid group and sulfonic acid amide group; ether group, thioether group, acylated hydroxyl, sulfonylamide, sulfonylurea, sulfoxide group, sulfone group and mixtures thereof; each n is the same and is 0 or 1; q is from 0-4; and, X is the anion of an acid.

Bis-acyloxymethyl derivatives

This invention relates to new bis(acyloxymethyl)imidazole derivatives; to compositions comprising these derivatives; and to processes for their utility as fungicides, bactericides and as inhibitors of the growth of cancer, particularly solid tumor cancer, in warm blooded animals of the formula: ##STR1## wherein M is ##STR2## or R; each R, R' and R' are independently selected from hydrogen and Z substituted or unsubstituted alkyl, cycloalkyl, cycloalkenyl, alkenyl, aryl, and heterocyclic ring wherein said ring comprises at least one of oxygen, nitrogen, sulfur or silicon; provided that ##STR3## may form a Z substituted or unsubstituted heterocyclic, and R' and R' attached to the imidazole ring, may form a Z substituted or unsubstituted heterocyclic ring; X is selected from at least one of oxygen, sulfur, nitrogen and alkyl; provided further that silicon is not directly attached to oxygen, sulfur or nitrogen and R' is not hydrogen when X is oxygen or sulfur; and Z is selected from halogen, nitro, nitrile, alkyl, haloalkyl, alkenyl, carboxylic acid, carboxylic acid ester, carboxylic acid amide, ether, thioether, hydroxyl, acylated hydroxyl, sulfonylamide, sulfonylurea, sulfoxide, sulfone, substituted and unsubstituted amine or mixtures thereof.

Bis(acyloxmethyl)imidazole compounds

This invention relates to new cis diamino platinum complexes; to compositions comprising these complexes; and to processes for their utility as fungicides, bacteriocides and as inhibitors of the growth of cancer in warm-blooded animals, wherein the complex is of the formula: [B(CH.sub.2).sub.n NH.sub.2 ].sub.2 Pt-M and ##STR1## wherein Pt is platinum II or platinum IV; M is selected from Y.sub.2, cyclic ##STR2## cyclic ##STR3## and cyclic ##STR4## when Pt is platinum II and X.sub.4 when Pt is platinum IV; each a is independently 1 or 2; n is from 0-3; each Y is independently --Cl, --Br, --I, --OH, --ONO.sub.2, --OSO.sub.3 and ##STR5## each X is independently selected from Y and two equatorial X's can together further be cyclic ##STR6## or cyclic ##STR7## each B is independently selected from aminoalkyl(dialkylsily), aminoalkyl(diphenylsilyl), triphenylsilyl, trialkylsilyl, aminoalkyl(alkyl,phenylsilyl), 2-amino-3,3-dialkyl-3-silacyclo-alkyl, 2-amino-3,3-diphenyl-3-silacycloalkyl, 2-amino-4,4-dialkyl-4-silacycloalkyl, 2-amino-4,4-diphenyl-4-silacycloalkyl and 1-aminoalkyl-1-silacycloalkyl; each R is independently selected from hydrogen and Z substituted and unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkynyl and aryl, provided that two R's attached to the same or adjacent carbon atoms, or two R's attached through different carbon atoms to the silicon atom, can form Z substituted or unsubstituted alkyl or aryl cyclic ring; and, Z is selected from haloge

Platinum complexes derived from b-silyamines

This invention provides a method of providing treatment to a warm blooded animal in need of treatment of a solid cancer tumor of the colon or breast comprising administering an effective amount of a pyrrole of the formula: ##STR1##

Method of treatment of solid cancer tumor of the colon or breast using

This invention provides a method of providing treatment to a warm blooded animal in need of treatment of a solid cancer tumor comprising administering an effective amount of a isopropylpyrrolizine of the formula: ##STR1##

Method of solid cancer tumor treatment using isopropylpyrrolizine

There is provided a method of synthesizing tetrachlorocyclohexanediammine platinum (IV) compounds in high purity and yield, the level of purity being suitable for pharmacological use. The compounds produced by this process have antineoplastic agents against tumor cells resistant to cis-platinum.

Growing community of inventors

Williamsville, NY, United States of America

Wayne K Anderson