Wyeth

Wayne G McMahon

John Potoski

Silvio Iera

Arthur G Mohan

Maria Papamichelakis

Christopher Demerson

Jacqueline F Lunetta

Michael F MacEwan

Jean Louise Helom

Xinxu Shi

Antonia Nikitenko

Vladimir Dragan

The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.

Processes and compounds for the preparation of substituted naphthylindole derivatives

The present invention provides a new process and intermediates for the production of antiviral compound 4',4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2&#x2032;-disulfonic acid and its pharmaceutically acceptable salts.

Preparation and purification of antiviral disulfonic acid disodium salt

The present invention provides a new process and intermediates for the production of antiviral compound 4&prime;,4-bis-&lcub;4,6-bis-&lsqb;3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino&rsqb;-&lsqb;1,3,5&rsqb;triazin-2-ylamino&rcub;-biphenyl-2,2&prime;-disulfonic acid and its pharmaceutically acceptable salts.

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Harriman, NY, United States of America

Wayne G McMahon