Japan Tobacco Inc.

Matsushita Electric Industrial Co., Ltd.

Wataru Watanabe

Yuji Matsuzaki

Shuichi Wamaki

Hiroshi Kawakami

Hisashi Shinkai

Motohide Satoh

Hisateru Aramaki

Takashi Ichiyanagi

Takahisa Motomura

Kazunobu Yamataka

Yoshiharu Itoh

Shinichi Kiyonari

Takashi Matsuda

Susumu Miyazaki

Kiyokazu Imanishi

Mitsuru Takahashi

Satoshi Okuda

Kiyoshi Kobata

Susumu Katoh

Satoru Kobayashi

Hirotaka Isoshima

Kaoru Adachi

Mitsuki Kano

Naohito Yamada

Akemi Nagao

Satoru Ikeda

The present invention relates to a combination therapy for treating an HIV infection or inhibiting integrase comprising (S)-6-(3-Chloro-2-fluorobenzyl)-1-(1-hydroxymethyl-2-methylpropyl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ('Compound A') or a pharmaceutically acceptable solvate or salt thereof in combination with at least one other anti-HIV agent. In some embodiments of the present invention, the other anti-HIV agents are chosen from reverse transcriptase inhibitors and protease inhibitors. In certain embodiments of the present invention, the other anti-HIV agents are chosen from AZT, 3TC, PMPA, efavirenz, indinavir, nelfinavir, a combination of AZT/3TC, and a combination of PMPA/3TC. Since Compound A has a high inhibitory activity specific for integrases, when used in combinations with other anti-HIV agents it can provide a combination therapy with fewer side effects for humans.

Combination therapy

An anti-HIV agent containing, as an active ingredient, a 4-oxoquinoline compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compound can become a more effective anti-HIV agent. Since the compound has high inhibitory activity specific for integrases, it can provide a safe pharmaceutical agent with a fewer side effects for human.

4-oxoquinoline compound and use thereof as HIV integrase inhibitor

Provision of a compound having an anti-HIV activity, particularly an integrase inhibitory activity. A 4-oxoquinoline compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification. The present invention also relates to a pharmaceutical composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; an integrase inhibitor, an antiviral agent, anti-HIV agent, and the like, which contains the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient; an anti-HIV composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and one or more other kinds of anti-HIV activity substances as active ingredients; an anti-HIV agent containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient, which is used for a multiple drug therapy with other anti-HIV agent(s), and the like.

The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Because it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.

Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor

4-oxoquinoline compound and use thereof as pharmaceutical agent

Method and apparatus for adjusting the position of a magnetic head

A magnetic recording/reproducing apparatus for recording information on a disc-like recording medium and/or for reproducing the recorded information therefrom. The magnetic recording/reproducing apparatus has a pair of magnetic head devices each composed of a magnetic head chip and a sliding pad for slidably holding the disc-like recording medium therebetween under a predetermined contact pressure. The magnetic head chip is surrounded at a predetermined interval by the sliding pad and the top portion of the magnetic head chip is disposed so as to protrude by a predetermined amount from a sliding surface of the sliding pad which comes into contact with the said disc-like recording medium. The pair of recording head devices are aligned with each other with the disc-like recording medium being held therebetween so that the magnetic head chips are arrranged at different positions at the same interval with respect to the sliding pads in a radial direction of the disc-like recording medium. When the interval from each of the magnetic head chips to each of the sliding pads is a and the interval between said magnetic head chips is b, the positions of the magnetic head chips with respect to the sliding pads are determined so as to satisfy the following relation,

Recording/reproducing head providing evenly distributed contact pressure

A magnetic recording and/or reproducing device for recording information on a disc-like magnetic recording medium and/or reproducing the information from it, said magnetic recording and/or reproducing device having a pair of magnetic head members each composed of a magnetic head chip and a slide pad for slidably holding the disc-like magnetic recording medium at its both surfaces between the pair of magnetic head members under a predetermined contact pressure, wherein the slide pad is so disposed as to surround the magnetic head chip and the top portion of the magnetic head chip is so disposed as to protrude by a predetermined amount from a sliding contact surface between the slide pad and the disc-like magnetic recording medium. It makes possible by the magnetic recording and/or reproducing device of the above described type to obtain such a desirable state in which the disc-like magnetic recording medium can be steadily held in contact with the magnetic head chips, since the slide pads act primarily to minimize the warp of the disc-like magnetic recording medium and also the deformation of the disc-like magnetic recording medium which would result from a deviation in position of one or both of the magnetic head members relative to the disc-like magnetic recording medium.

Flexible recording medium tensioning magnetic recording head

Growing community of inventors

Osaka, Japan

Wataru Watanabe